IL10RB / IL10R2 Antikörper (Antigen Affinity Purified)

10.08.2012

Produkt-Information von IL10RB / IL10R2 Antikörper

Immunogen	Recombinant Mouse IL10RB / IL10R2 protein (Catalog#50846-M08H)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Mouse IL10RB / IL10R2 (rM IL10RB / IL10R2; Catalog#50846-M08H; NP_032375.2; Met 1-Ser 222). IL10RB / IL10R2 specific IgG was purified by Mouse IL10RB / IL10R2 affinity chromatography.

Usage Guide von IL10RB / IL10R2 Antikörper

Specificity	Mouse IL10RB / IL10R2
Western blot	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse IL10RB in WB. Using a DAB detection system, the detection limit for Mouse IL10RB is approximately 1 ng/lane under non-reducing conditions and 0.5 ng/lane under reducing conditions.
Direct ELISA	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse IL10RB. The detection limit for Mouse IL10RB is approximately 0.00975 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Verwandte Produkte & Themen von IL10RB / IL10R2 Antikörper

Related Areas:

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IL-10RB/CDw210b

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-10/Interferon Family>>IL-10RB/CDw210b

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>IL-10RB/CDw210b

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Monocyte Markers>>IL-10RB/CDw210b

Immunology>>Cluster of Differentiation>>Natural Killer (NK) Cell CD Antigen>> IL-10RB/CDw210b

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells>> IL-10RB/CDw210b

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IL-10RB	Human	IL-10RB/Fc Protein, Recombinant	10945-H03H
IL-10RB	Human	IL-10RB Protein, Recombinant	10945-H08H
IL-10RB	Mouse	IL-10RB Protein, Recombinant	50846-M02H
IL-10RB	Mouse	IL-10RB Protein, Recombinant	50846-M08H
IL-10RB	Rat	IL10RB / IL10R2 Protein, Recombinant	80184-R02H

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human IL10RB	WB, ELISA	Mouse Monoclonal Antibody	10945-MM02
Human IL10RB	WB, ELISA	Rabbit Polyclonal Antibody	10945-RP01
Human IL10RB	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10945-RP02
Mouse IL10RB	WB, ELISA	IL10RB / IL10R2 Antibody (Antigen Affinity Purified)	50846-RP02

Hintergrund von IL10RB / IL10R2 Antikörper

The functional IL-10 receptor consists of two polypeptide chains, a ligand binding chain IL-10 Rα (IL-10 R1) and a signal transduction molecule known as IL-10 Rβ (IL-10 R2). Both chains of the IL-10 R are expressed on many hematopoietic cells, including lymphocytes, monocytes and neutrophils, with the IL-10 Rβ chain expressed at higher levels than the IL-10 Rα chain in most cases. Interleukin 10 receptor beta (IL-10 Rβ), also known as CD210b and CRF2-4, is an 80-85 kDa member of the type II cytokine receptor family of proteins and contains two fibronectin type-III domains. The widely expressed IL-10 Rβ serves as a signal transducing accessory chain not only for IL-10, but also for other interleukins including IL-22, -28A, -28B and -29 (plus IL-26 in human) when complexed to the ligand-binding chains. It has been shown that the action of IL-10 delivered through its receptor can affect a variety of immune functions including inhibition of pro-inflammatory cytokine synthesis and regulation of the growth and function of B cells and antigen presenting cells. The human IL-10 Rβ shares 69% homology to its mouse counterpart in amino acid sequence. Research evidences indicated that defects in IL10RB are associated with susceptibility to hepatitis B virus infection.

References

Liu, Y. et al., 1994, J. Immunol. 152: 1821-1829.
Kotenko, S.V. et al.,1997, EMBO J. 16 (19): 5894-5903.
Gibbs, V. C. et al., 1997, Pennica. Gene 186: 97-101.
Kotenko, S.V. et al., 2001, J. Biol. Chem. 276: 2725-2732.
Crepaldi, L. et al., 2001, J. Immunol. 167: 2312-2322.
Dinant, S. J. et al., 2007, Surg Res. 141 (2): 176-82.

Sino Biological Inc. liefert IL10RB / IL10R2 Antikörper (Antigen Affinity Purified) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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