IL-1 alpha / IL-1F1 / IL1A Antikörper

27.08.2012

Produkt-Information von IL-1 alpha / IL-1F1 / IL1A Antikörper

Immunogen	Recombinant Mouse IL-1 alpha / IL-1F1 / IL1A protein (Catalog#50114-MNAE)
Antibody Type	Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
Clone ID	024
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	3This antibody was obtained from a rabbit immunized with purified, recombinant Mouse IL-1 alpha / IL-1F1 / IL1A (rM IL-1 alpha / IL-1F1 / IL1A; Catalog#50114-MNAE; NP_034684.2; Ser 115-Ser 270).

Usage Guide von IL-1 alpha / IL-1F1 / IL1A Antikörper

Specificity	Mouse IL-1 alpha / IL-1F1 / IL1A
	No cross-reactivity in ELISA with Human IL1A
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Mouse IL1A in WB.
Direct ELISA	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse IL1A. The detection limit for Mouse IL1A is approximately 0.078 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Related Areas:

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IL-1 alpha/IL-1F1

Immunology>>Cytokine & Receptor>>Interleukin & Receptor >>IL-1 superfamily and IL-1R/TLR family>>IL-1 alpha/IL-1F1

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IL-1 alpha/IL-1F1	Human	IL-1 alpha/IL-1F1 Protein, Recombinant	10128-HNCH
IL-1 alpha/IL-1F1	Mouse	IL-1 alpha/IL-1F1 Protein, Recombinant, with Native	50114-MNAE

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Mouse IL-1 alpha/IL-1F1	WB, ELISA	IL-1 alpha / IL-1F1 / IL1A Antibody (Antigen Affinity Purified)	50114-RP02
Mouse IL-1 alpha/IL-1F1	WB, ELISA	IL-1 alpha / IL-1F1 / IL1A Antibody	50114-R024

Hintergrund von IL-1 alpha / IL-1F1 / IL1A Antikörper

Interleukin 1 (IL1) is an important cytokine mediator involved in a variety of biological processes including immune responses, inflammatory, and promoting tissue degradation. IL1 comprises two proteins, designated as IL-1 alpha/IL1α and IL-1 beta/IL1β which are encoded by distinct genes, and bind the same surface receptors with high affinity. IL1 proteins are synthesized as 31 kDa cytosolic precursors in monocytes and macrophages without signal peptides, and are proteolytically processed and released as 17kDa mature molecules in response to various stimulus not via the classical secretory pathway. It has been reported that release of IL1 is efficiently induced by cell injury. IL-1 alpha/L1α is released as a mixture of unprocessed and processed molecules cleaved by a calpain-like protease, and both of the forms show full biological activity. Elevated levels of IL-1 alpha/IL1α have been associated with a number of chronic disorders, including rheumatoid arthritis and Alzheimer's disease, and therefore, may provide novel targets for therapeutic approaches aimed at controlling inflammatory processes.

References

Dinarello, C. A. et al., 1996, Blood. 87: 2095-2147.
Hogguist, K.A. et al., 1991, Proc. Natl. Acad. Sci. 88: 8485-8489.
Griffin, W.S. et al. 2002, J. Leukoc. Biol. 72: 233-238.
Perreqaux, D.G. et al., 1998, J. Immunol. 160: 2469-2477.
Brunn, G.J. et al., 2008, Circ. Res. 102: 823-830.

Sino Biological Inc. liefert IL-1 alpha / IL-1F1 / IL1A Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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