IDO1 / IDO Protein

Produkt-Information von IDO1 / IDO Protein

QC Testing von IDO1 / IDO Protein

Purity	> 85 % as determined by SDS-PAGE	SDS-PAGE: IDO1 / IDO protein
Bio-activity	Measured by its ability to oxidize L-tryptophan to N-formylk-ynurenine. The specific activity is > 500 pmoles/min/μg.
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Gly
Molecular Mass	The recombinant human IDO1 consists of  405 amino acids and predicts a molecular mass of 45.2 KDa. It migrates as an approximately 42 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of 50mM NaAC,100mM NaCl,  20%glycerol, pH5.5. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von IDO1 / IDO Protein

Verwandte Produkte & Themen von IDO1 / IDO Protein

Besschreibung von IDO1 / IDO Protein

Indoleamine 2,3-dioxygenase-1, also known as Indoleamine-pyrrole 2,3-dioxygenase, IDO1 and IDO, is a member of the indoleamine 2,3-dioxygenase family. IDO1 / IDO and tryptophan 2,3-dioxygenase (TDO) are tryptophan-degrading enzymes that catalyze the first step in tryptophan catabolism via the kynurenine pathway. TDO is widely distributed in both eukaryotes and bacteria. In contrast, IDO has been found only in mammals and yeast. In 2007, a third enzyme, indoleamine 2,3-dioxygenase-2 (IDO2), was discovered. IDO2 is found not only in mammals but also in lower vertebrates. IDO1 / IDO is an immunosuppressive molecule inducible in various cells. IDO1 / IDO catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen. It mediates oxidative cleavage of tryptophan, an amino acid essential for cell proliferation and survival. IDO1 / IDO inhibition is proposed to have therapeutic potential in immunodeficiency-associated abnormalities, including cancer. The IDO pathway is activated in multiple tumor types. Selective inhibition of IDO1 may represent an attractive cancer therapeutic strategy via up-regulation of cellular immunity. IDO1 / IDO is an enzyme that suppresses adaptive T-cell immunity by catabolizing tryptophan from the cellular microenvironment. Inhibition of IDO pathway might enhance the efficacy of immunotherapeutic strategies for cancer.

References

1. Barnes NA. et al., 2009, J Immunol. 183 (9): 5768-77.
2. Yuasa HJ. et al., 2009, Comp Biochem Physiol B Biochem Mol Biol. 153 (2): 137-44.
3. L b S. et al., 2009, Cancer Immunol Immunother. 58 (1): 153-7.
4. Liu,X. et al., 2010, Blood.115 (17): 3520-30.
5. Sun,T. et al., 2010, Mol Cell Biochem. 342 (1-2): 29-34.
6. Kiank C. et al., 2010, PLoS One. 5 (7): e11825.

Sino Biological Inc. liefert IDO1 / IDO Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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