HSPD1 / HSP60 Antikörper (Antigen Affinität reinigt)

07.02.2012

Produkt-Information von HSPD1 / HSP60 Antikörper

Immunogen	Recombinant Mouse HSPD1 / HSP60 protein (Catalog#50596-M07E)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Mouse HSPD1 / HSP60 (rM HSPD1 / HSP60; Catalog#50596-M07E; NP_034607.3; Leu 2-Phe 573). HSPD1 / HSP60 specific IgG was purified by Mouse HSPD1 / HSP60 affinity chromatography.

HSPD1 / HSP60 Antikörper Usage Guide

Specificity	Mouse HSPD1 / HSP60
Western blot	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse HSP60 in WB. Using a DAB detection system, the detection limit for Mouse HSP60 is approximately 2 ng/lane under non-reducing conditions and 16 ng/lane under reducing conditions.
Direct ELISA	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse HSP60. The detection limit for Mouse HSP60 is approximately 0.039 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von HSPD1 / HSP60 Antikörper

60 kDa heat shock protein, mitochondrial, also known as 60 kDa chaperonin, Chaperonin 60, Heat shock protein 60, HSP-60, Mitochondrial matrix protein P1, HSPD1 and HSP60, is a mitochondrion matrix protein which belongs to thechaperonin (HSP60) family. HSPD1 / HSP60 is implicated in mitochondrial protein import and macromolecular assembly. It may facilitate the correct folding of imported proteins. HSPD1 / HSP60 may also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. Defects in HSPD1 are a cause of spastic paraplegia autosomal dominant type 13 (SPG13) which is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Defects in HSPD1 are also the cause of leukodystrophy hypomyelinating type 4 which is a severe autosomal recessive hypomyelinating leukodystrophy. Clinically characterized by infantile-onset rotary nystagmus, progressive spastic paraplegia, neurologic regression, motor impairment, profound mental retardation. Death usually occurrs within the first two decades of life.

References

Singh B., et al., 1990, Biochem. Biophys. Res. Commun. 169:391-6.
Rasmussen R.K., et al., 1997, Electrophoresis 18:588-98.
Hansen J.J., et al., 2002, Am. J. Hum. Genet. 70:1328-32.
Hansen J.J., et al., 2003, Hum. Genet. 112:71-77.
Magen D., et al., 2008, Am. J. Hum. Genet. 83:30-42.

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