HAVCR1 / TIM1 / KIM1 Antikörper

02.02.2012

Produkt-Information von HAVCR1 / TIM1 / KIM1 Antikörper

Immunogen	Recombinant Human HAVCR1 protein (Catalog#11051-H07H)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Human HAVCR1 / TIM1 / KIM1 (rh HAVCR1 / TIM1 / KIM1; Catalog#11051-H07H; AAC39862.1; Ser 21-Gly 290). Total IgG was purified by Protein A affinity chromatography.

HAVCR1 / TIM1 / KIM1 AntikörperUsage Guide

Specificity	Human HAVCR1 / TIM1 / KIM1
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human KIM1 in WB.
Direct ELISA	This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human KIM1. The detection limit for Human KIM1 is approximately 0.039 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von HAVCR1 / TIM1 / KIM1 Antikörper

Hepatitis A virus cellular receptor 1 (HAVCR1), also known as T cell immunoglobulin and mucin domain-containing protein 1 (TIMD1) and T cell membrane protein 1 (TIM1), is a member of the TIM family, an immunologically important group of receptors that is conserved in vertebrates. TIM1 is widely expressed with highest levels in kidney and testis. It has been shown that mouse HAVCR1 is expressed by stimulated T-cells during primary antigen stimulation and associates with immunomodulatory properties. TIM1 is a type 1 integral membrane glycoprotein, and in the ECD contains one V-type Ig-like domain extended above the cell surface by a mucin-like domain characterized by a variable number of threonine, serine, and proline (TSP) hexameric repeats. TIM1 plays a critical role in T-helper cell development and the regulation of asthma and allergic diseases. In addition to HAV, another identified ligand for TIM1 is TIMD4. Rat TIM1 ECD shares 50% and 81% amino acid sequence homology with human and mouse TIM1 ECD rexpectively.

References

Silberstein E. et al., 2001, J Virol. 75 (2): 717-25.
Silberstein E. et al., 2003, J Virol. 77 (16): 8765-74.
Tami C. et al., 2007, J Virol. 81 (7): 3437-46.
Garner-Spitzer E. et al., 2009, Vaccine. 27 (2): 197-204

Sino Biological Inc. liefert HAVCR1 / TIM1 / KIM1 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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