gp130 / CD130 / IL6ST Antikörper

25.06.2012

Produkt-Information von gp130 / CD130 / IL6ST Antikörper

Immunogen	Recombinant Rat gp130 / CD130 / IL6ST protein (Catalog#80030-R08H)
Antibody Type	Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
Clone ID	9D7A9
Ig Type	Mouse IgG2b
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat gp130 / CD130 / IL6ST (rR gp130 / CD130 / IL6ST; Catalog#80030-R08H; NP_001008725.2; Met 4-Glu 618). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.

Usage Guide von gp130 / CD130 / IL6ST Antikörper

Specificity	Rat gp130 / CD130 / IL6ST
	No cross-reactivity in WB and ELISA with Human cell lysate (293 cell line)
Direct ELISA	This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Rat IL6ST. The detection limit for Rat IL6ST is approximately 0.039 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Verwandte Produkte & Themen von gp130 / CD130 / IL6ST Antikörper

Related Areas:

Neuroscience>>Neurotrophic Factor & Receptor>>Other Neurotrophic Factors>>gp130/IL6ST/CD130

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-6 Family & Receptor>>gp130/IL6ST/CD130

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-12 Family & Receptor>>gp130/IL6ST/CD130

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>gp130/CD130

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells>>gp130/CD130

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
gp130/CD130	Human	gp130/CD130/Fc Protein, Recombinant	10974-H03H
gp130/CD130	Mouse	gp130/CD130 Protein, Recombinant	50135-M03C
gp130/CD130	Mouse	gp130/CD130 Protein, Recombinant	50135-M08H
gp130/CD130	Rat	gp130/CD130 Protein, Recombinant	80030-R06H
gp130/CD130	Rat	gp130/CD130 Protein, Recombinant	80030-R08H
gp130/CD130	Mouse	IL6ST / gp130 / CD130 Protein, Recombinant	50135-M03H

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Mouse gp130/CD130	WB, ELISA	gp130 / CD130 / IL6ST Antibody	50135-RP01
Mouse gp130/CD130	WB, ELISA	gp130 / CD130 / IL6ST Antibody (Antigen Affinity Purified)	50135-RP02
Rat gp130/CD130	WB, ELISA	gp130 / CD130 / IL6ST Antibody	80030-MM04
Rat gp130/CD130	WB, ELISA	gp130 / CD130 / IL6ST Antibody	80030-MM08

Hintergrund von gp130 / CD130 / IL6ST Antikörper

Glycoprotein 130 (gp130), also known as IL6ST, IL6R-beta and CD130, is a common signal-transducing molecule shared by the functional receptor complexes of the IL-6 family of cytokines (IL-6, IL-11, leukemia inhibitory factor (LIF), granulocyte colonystimulating factor, ciliary neurotrophic factor, and cardiotrophin-1). It belongs to the class I cytokine receptor family, and was found in tissues such as brain, heart, thymus, spleen, kidney, lung and liver. Mouse gp130 contains five fibronectin type-III domains, and one Ig-like C2-type (immunoglobulin-like) domain. gp130 is an important part of many different types of signaling complexes. It binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. This complex of 3 proteins then homodimerizes to form a hexameric complex which can produce downstream signals. Inactivation of gp130 is lethal to mice. The mice homozygous for a knock-in mutation in gp130 that leads to gp130-dependent signal transducers and activators of transcription (STAT) 1/3 hyperactivation develop a broad spectrum of hematopoietic abnormalities, including splenomegaly, lymphadenopathy, and thrombocytosis. gp130 is also involved in various human diseases, such as liver disease, coronary artery disease and myocardial infarction. Furthermore, gp130 is widely expressed in breast cancer cell lines and primary tumors, thus it have been implicated in constitutive STAT3 activation in breast cancer.

References

Saito, M. et al., 1992, J Immunol. 148 (12): 4066-4071.
Murakami, M. et al., 1993, Science. 260 (5115): 1808-1810.
Yoshida, K. et al., 1996, Proc Natl Acad Sci. 93 (1): 407-411.
Selander, K.S. et al., 2004, Cancer Res. 64 (19): 6924-6933.
Jenkins, B.J. et al., 2005, Blood. 105 (9): 3512-3520.
Luchtefeld, M. et al., 2007, J Exp Med. 204 (8): 1935-1944.

Sino Biological Inc. liefert gp130 / CD130 / IL6ST Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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