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| Immunogen | Recombinant Human GFRA2 protein (Catalog#10331-H08H) |
| Antibody Type | Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform ) |
| Clone ID | 101 |
| Ig Type | Rabbit IgG |
| Formulation | 0.2 μm filtered solution in PBS with 5% trehalose |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Human GFRA2 (rh GFRA2; Catalog#10331-H08H; NP_001486.4; Met 1-Ser 441). |
| Specificity | Human GFRA2 |
| No cross-reactivity in ELISA with Human GFRa3 | |
| Western blot | This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human GFRA2 in WB. Using a DAB detection system, the detection limit for Human GFRA2 is approximately 20 ng/lane under non-reducing conditions and 1 ng/lane under reducing conditions. |
| Direct ELISA | This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human GFRA2. The detection limit for Human GFRA2 is approximately 0.078 ng/well. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. |
GDNF family receptor alpha-2, also known as GFR-alpha-2, Neurturin receptor alpha, TGF-beta-related neurotrophic factor receptor 2, GFRA2, GFRα-2, and GDNFRB, is a cell membrane protein which belongs to theGDNFR family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF is a glycosylated, disulfide-bonded homodimer that is distantly related to the TGF-beta superfamily of growth factors. Three receptors for these factors, GFRα-1, GFRα-2 and GFRα-3 have been identified. These receptors do not contain transmembrane domains and are attached to the cell membrane by GPI linkage. Both GFRα-1 and GFRα-2 have been shown to mediate the GDNF-dependent and NTN-dependent phosphorylation and activation of the tyrosine kinase Ret which is necessary for kidney and enteric neuron development. GFRα-1 is the primary receptor for GDNF and GFRα-2 exhibits a preference for NTN. GFRα-2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It can also mediate GDNF signaling through the RET tyrosine kinase receptor.
Sino Biological Inc. liefert GFRA2 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.
Weitere Informationen über GFRA2 Antikörper lesen Sie bitte: http:www.sinobiological.com/GFRA2-Antibody-g-9188.html
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