Fragile histidine triad / FHIT Protein (His Tag)

26.03.2013

Sino Biological Inc. liefert Fragile histidine triad / FHIT Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Fragile histidine triad / FHIT Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/Fragile-histidine-triad-FHIT-Protein-Antibody-a-5739.html

Produkt-Information von Fragile histidine triad / FHIT Protein

Synonym	FHIT
Protein Construction	A DNA sequence encoding the human FHIT (P49789) (Met1-Gln147) was expressed with a polyhistidine tag at the C-terminus.
Source	Human
Expression Host	E.coli

QC Testing von Fragile histidine triad / FHIT Protein

Purity	> 85 % as determined by SDS-PAGE	SDS-PAGE: FHIT protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant human FHIT consists of 153 amino acids and predicts a molecular mass of 17.7 KDa. It migrates as an approximately 18 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile 50mM Tris, 10% glycerol, pH 8.0. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von Fragile histidine triad / FHIT Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von Fragile histidine triad / FHIT Protein

Fragile histidine triad, also known as FHIT, may play a key role in differentiating humans from apes. Fragile histidine triad gene belongs to the histidine triad gene family. The exact molecular function of FHIT is still partially unclear. It has been shown that fragile histidine triad synergizes with VHL, another tumor suppressor, in protecting against chemically - induced lung cancer. Fragile histidine triad gene works as a tumor suppressor as it has been demonstrated in animal studies. It also acts as a tumor suppressor of HER2/neu driven breast cancer.

References

Lambert N. et al., 2006, Nature. 443 (7108): 167-72.
Pekarsky Y. et al., 1998, Proc Natl Acad Sci. 95 (15): 8744-9.
Ohta M. et al., 1996, Cell. 84 (4): 587-97.