FKBP14 Protein (His Tag)

22.03.2013

Sino Biological Inc. liefert FKBP14 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über FKBP14 Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/FKBP14-Protein-Antibody-a-5748.html

Produkt-Information von FKBP14 Protein

Synonym	FKBP14, FKBP22
Protein Construction	A DNA sequence encoding the human FKBP14 (Q9NWM8) (Met1-Lys207) was expressed with a polyhistidine tag at the C-terminus.
Source	Human
Expression Host	Human Cells

QC Testing von FKBP14 Protein

Purity	(73.1+25.2) % as determined by SDS-PAGE	SDS-PAGE: FKBP14 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Ala 20
Molecular Mass	The recombinant human FKBP14 consists of 199 amino acids and predicts a molecular mass of 22.9 KDa. It migrates as an approximately 25 and 27 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von FKBP14 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von FKBP14 Protein

FKBP14 is a member of the FK506-binding protein family. It contains 2 EF-hand domains and one PPIase FKBP-type domain. Truncation of the amino-terminus of FKBP14 significantly decreases peptidyl prolyl cis-trans isomerase activity, therefore implicating that the PPIase FKBP-type domain must be located at the N-terminus. FKBP14 can be detected in the lumen of the endoplasmic reticulum where it is thought to accelerate the folding of proteins during protein synthesis. Defects in FKBP14 can cause Ehlers-Danlos syndrome with progressive kyphoscoliosis, myopathy, and hearing loss. A syndrome with features of Ehlers-Danlos syndrome types VIA and VIB on the one hand, and the collagen VI-related congenital myopathies Ullrich congenital muscular dystrophy and Bethlem myopathy on the other hand.

References

Baker K. et al., 2003, Genome Res. 13: 2265-70.
Ota T. et al., 2004, Nat Genet. 36: 40-5.
The MGC Project Team. 2004, Genome Res. 14: 2121-7.