FGFR2 / CD332 (aa 400-821) Protein (GST Tag)

30.05.2012

Produkt-Information von FGFR2 / CD332 Protein

Synonym	BEK, BFR-1, CD332, CEK3, CFD1, ECT1, FLJ98662, JWS, K-SAM, KGFR, TK14,TK2
Protein Construction	A DNA sequence encoding the human FGFR2 (NP_000132.3) cytoplasmic domain (Met 400-Thr 821) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
Source	Human
Expression Host	Baculovirus-Insect cells

QC Testing von FGFR2 / CD332 Protein

Purity	> 92 % as determined by SDS-PAGE	SDS-PAGE: FGFR2 / CD332 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Gln 26
Molecular Mass	The recombinant human FGFR2 (aa 400-821) /GST chimera consists of 659 amino acids and predictes a molecular mass of 75.7 kDa. It migrates as an approximately 68 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from 0.2μm filtered solution of 20mM Tris, 500mM NaCl, pH7.4, 10%gly. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von FGFR2 / CD332 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Verwandte Produkte & Themen von FGFR2 / CD332 Protein

Related Areas:

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>FGFR2/CD332

Neuroscience>>Axon Guidance>>FGF & Receptor>>FGFR2/CD332

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>FGFR2/CD332

Stem Cell>>Neural Stem Cell (NSC)>>Glial Cell Markers>>FGFR2/CD332

Cancer>>Growth Factor & Receptor>>FGF & Receptor>>FGFR2/CD332

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>FGFR2/CD332

Immunology>>Cluster of Differentiation>>Other>>FGFR2/CD332

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
FGFR2/CD332	Human	FGFR2/CD332/Fc Protein, Recombinant	10824-H03H
FGFR2/CD332	Human	FGFR2/CD332 Protein, Recombinant	10824-H08H
FGFR2/CD332	Human	FGFR2 / CD332 (aa 400-821) Protein, Recombinant, with GST Tag	10824-H20B1

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human FGFR2/CD332	WB, ELISA	FGFR2/CD332 Antibody, Rabbit MAb	10824-R106
Human FGFR2/CD332	WB, ELISA	Rabbit Polyclonal Antibody	10824-RP01
Human FGFR2/CD332	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10824-RP02

Beschreibung von FGFR2 / CD332 Protein

Fibroblast growth factor receptor 2 (FGFR2) is a member of the fibroblast growth factor receptor (FGFR) subfamily belonging to the Tyr protein kinase family, and amino acid sequence of which is highly conserved between members throughout evolution. FGFR family members differ from one another in their ligand affinities , tissue distribution and have been implicated in a multitude of activities. FGFR2 is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. This protein consists of an extracellular region composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. Mutations in the FGFR2 gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis.

References

Santos-Ocampo S. et al., 1996, J Biol Chem. 271 (3): 1726-31.
Stauber DJ. et al., 2000, Proc Natl Acad Sci. 97 (1): 49-54.
Pellegrini L. et al., 2000, Nature. 407 (6807): 1029-34.
Yu S. et al., 2002, Am J Physiol Endocrinol Metab. 283 (3): E490-5.
Hunter DJ. et al., 2007, Nature Genetics. 39: 870-4.

Sino Biological Inc. liefert FGFR2 / CD332 (aa 400-821) Protein (GST Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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