ErbB3 / HER3 Antikörper

14.11.2012

Sino Biological Inc. liefert ErbB3 / HER3 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über ErbB3 / HER3 Antikörper lesen Sie bitte: http://www.sinobiological.com/ErbB3-HER3-Antibody-g-10147.html

Produkt-Information von ErbB3 / HER3 Antikörper

Immunogen	Recombinant Rhesus ErbB3 / HER3 protein (Catalog#90043-C08H)
Antibody Type	Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
Clone ID	05
Ig Type	Mouse IgG1
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rhesus ErbB3 / HER3 (Catalog#90043-K08H; XP_001113953.2; Met 1-Thr 643). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.

Usage Guide von ErbB3 / HER3 Antikörper

Specificity	Rhesus ErbB3 / HER3
	Has cross-reactivity in ELISA with Human ERBB3 Mouse ERBB3 No cross-reactivity in ELISA with Human cell lysate (293 cell line)
Direct ELISA	This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Rhesus ErbB3. The detection limit for Rhesus ErbB3 is approximately 0.039 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Verwandte Produkte & Themen von ErbB3 / HER3 Antikörper

Related Areas:

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>HER3/ErbB3

Cancer>>Cancer Biomarkers>>HER3/ErbB3

Cancer>>Growth Factor & Receptor>>EGF Family & Receptor>>HER3/ErbB3

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>HER3/ErbB3

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
HER3/ErbB3	Human	HER3/ErbB3/Fc Protein, Recombinant	10201-H02H
HER3/ErbB3	Human	HER3/ErbB3 Protein, Recombinant	10201-H08H
HER3/ErbB3	Human	ErbB3 / HER3 (aa 730-1065) Protein, with GST Tag	10201-H20B1
HER3/ErbB3	Mouse	HER3 / ErbB3 Protein, Recombinant	51003-M08H
HER3/ErbB3	Rat	ErbB3 / HER3 Protein, Recombinant	80111-R02H
HER3/ErbB3	Rat	ErbB3 / HER3 Protein, Recombinant	80111-R08H
HER3/ErbB3	Rhesus	HER3/ErbB3 Protein, Recombinant	90043-C02H
HER3/ErbB3	Rhesus	HER3/ErbB3 Protein, Recombinant	90043-C08H

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human HER3/ErbB3	WB, ELISA	HER3/ErbB3 Antibody, Rabbit PAb	10201-RP01
Human HER3/ErbB3	WB, ELISA	HER3/ErbB3 Antibody, Rabbit PAb (Antigen Affinity Purified)	10201-RP02
Human HER3/ErbB3	WB, ELISA	HER3 / ErbB3 Antibody	10201-R016
Human HER3/ErbB3	WB, ELISA	HER3 / ErbB3 Antibody	10201-MM01
Rhesus HER3/ErbB3	ELISA	ErbB3 / HER3 Antibody	90043-MM05

Hintergrund von ErbB3 / HER3 Antikörper

ErbB3, also known as Her3 (human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.

References

Kraus,M.H. et al., 1989, Proc. Natl. Acad. Sci. 86: 9193-9197.
Carraway, K.L. et al., 1994, J. Biol. Chem. 269: 14303 -14306.
Wallasch, C. et al., 1995, EMBO. J. 14: 4267-4275.
Alimandi, M. et al., 1995, Oncogene. 10:1813-1821.
Gamett, D.C. et al., 1995, J. Biol. Chem. 270: 19022-19027.
Katoh, M. et al., 1993, Biochem. Biophys. Res.Commun. 192: 1189-1197.