Ephrin-A2 / EFNA2 Antikörper

28.02.2012

Produkt-Information von Ephrin-A2 / EFNA2 Antikörper

Immunogen	Recombinant Mouse Ephrin-A2 / EFNA2 protein (Catalog#50579-M08H)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Mouse Ephrin-A2 / EFNA2 (rM Ephrin-A2 / EFNA2; Catalog#50579-M08H; NP_031935.3; Met 1-Asn 184). Total IgG was purified by Protein A affinity chromatography.

Ephrin-A2 / EFNA2 Antikörper Usage Guide

Specificity	Mouse Ephrin-A2 / EFNA2
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Mouse EFNA2 in WB.
Direct ELISA	This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Mouse EFNA2. The detection limit for Mouse EFNA2 is approximately 0.0195 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von Ephrin-A2 / EFNA2 Antikörper

Ephrin-A2, also known as EPH-related receptor tyrosine kinase ligand 6, LERK-6, HEK7 ligand, EFNA2 and EPLG6, is a cell membrane protein which belongs to the ephrin family. Ephrin-A2 / EFNA2 binds to the receptor tyrosine kinases EPHA3, EPHA4 and EPHA5. The ephrins (EPH) and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases (RTKs), and have been involved in a variety of biological processes, especially in the nervous system and in erythropoiesis, such as axon guidance and topographic map formation, synaptic plasticity, angiogenesis, and meanwhile have possible contributions to tumor growth and metastasis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class which are anchored to the membrane by a GPI linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. 14 receptors and 8 ligands have been reported in mammals.

References

Zhou, R. Pharmacol. Ther. 77: 151-181.
Stein, E. et al., 1999, J. Neurosci. 19: 8885-8893.
Cheng, N. et al., 2002, Cytokine. Growth. Factor. Rev. 13: 75-85.
Irie, F. et al., 2008, Proc. Nat. Acad. Sci. 105: 12307-12312.

Sino Biological Inc. liefert Ephrin-A2 / EFNA2 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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