Ephrin-A1 / EFNA1 Antikörper (Antigen Affinität reinigt)

24.02.2012

Produkt-Information von Ephrin-A1 / EFNA1 Antikörper

Immunogen	Recombinant Mouse Ephrin-A1 / EFNA1 protein (Catalog#50593-M08H)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Mouse Ephrin-A1 / EFNA1 (rM Ephrin-A1 / EFNA1; Catalog#50593-M08H; NP_612182.1; Met 1-Ser 182). Ephrin-A1 / EFNA1 specific IgG was purified by Mouse Ephrin-A1 / EFNA1 affinity chromatography.

Ephrin-A1 / EFNA1 Antikörper Usage Guide

Specificity	Mouse Ephrin-A1 / EFNA1
Western blot	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse EFNA1 in WB. Using a DAB detection system, the detection limit for Mouse EFNA1 is approximately 2 ng/lane under non-reducing conditions and 1 ng/lane under reducing conditions.
Direct ELISA	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse EFNA1. The detection limit for Mouse EFNA1 is approximately 0.00245 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von Ephrin-A1 / EFNA1 Antikörper

The ephrins (Eph) and Eph receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. All ephrins share a conserved extracellular sequence, which most likely corresponds to the receptor-binding domain. Inmolecular biology, ephrins and Eph receptorsare components ofcell signalingpathways involved inanimaldevelopment, and implicated in some cancers. Eph receptors are classified asreceptor tyrosine kinases (RTKs), and form the largest sub-family of RTKs. Almost all Eph receptors are expressed during various well defined stages of development in assorted locations and concentrations. Mouse ephrin-A1, also known as B61, LERK-1, and EFL-1, is a member of the ephrin ligand family which binds members of the Eph receptor family. Ephrin-A1 has been shown to bind EphA1, EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, and EphB1. The extracellular domains of human and mouse ephrin-A1 share 85% amino acid identity.

References

Cerretti, DP. et al.,1995,Mol. Immunol.32 (16): 1197-205.
Gale, NW. et al.,1996,Neuron.17 (1): 9-19.
Pasquale, EB. et al., 1997, Curr. Opin. Cell. Biol. 9 (5): 608-15.
Flanagan, J. et al., 1998,Annual Review of Neuroscience.21: 309-45.
Holder, N. et al., 1999, Development. 126 (10): 2033-44.
Wilkinson, DG. et al., 2001,Nat. Rev. Neurosci.2 (3): 155-64.
Murai, KK. et al., 2003,Journal of Cell Science.116 (Pt 14): 2823-32.

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