EBP1 / PA2G4 Protein (His Tag)

07.06.2012

Produkt-Information von EBP1 / PA2G4 Protein

Synonym	EBP1, HG4-1, p38-2G4
Protein Construction	A DNA sequence encoding the human PA2G4 (Q9UQ80) (Ser 2-Asp 394) was expressed, with a polyhistide tag at the N-terminus.
Source	Human
Expression Host	E.coli

QC Testing von EBP1 / PA2G4 Protein

Purity	> 92 % as determined by SDS-PAGE	SDS-PAGE: EBP1 / PA2G4 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met 1
Molecular Mass	The recombinant human PA2G4 consisting of 404 amino acids and has a calculated molecular mass of 45.2 kDa. It migrates as an approximately 32 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of 20mM Tris 0.5M NaCl pH 8.0. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von EBP1 / PA2G4 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von EBP1 / PA2G4 Protein

EBP1, also known as PA2G4, is an RNA-binding protein which belongs to the peptidase M24 family. It is expressed in several cell lines tested, including primary and transformed cell lines. EBP1 also present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. PA2G4 can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. EBP1 has been implicated in growth inhibition and the induction of differentiation of human cancer cells. It seems to be involved in growth regulation. EBP1 also mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site).

References

Yoo J Y. et al., 2000, Br J Cancer. 82 (3): 683-90.
Andersen JS. et al., 2002, Curr Biol. 12 (1): 1-11.
Lehner B. et al., 2004, Genome Res. 14 (7): 1315-23.

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