DSC2 Antikörper

20.02.2012

Produkt-Information von DSC2 Antikörper

Immunogen	Recombinant Human DSC2 protein (Catalog#10809-H08H)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Human DSC2 (rh DSC2;Catalog#10809-H08H; Q02487-1; Met 1-Arg 684). Total IgG was purified by Protein A affinity chromatography.

DSC2 Antikörper Usage Guide

Specificity	Human DSC2
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human DSC2 in WB.
Direct ELISA	This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Human DSC2. The detection limit for Human DSC2 is approximately 0.00975 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von DSC2 Antikörper

Desmocollin-2, also known as Cadherin family member 2, Desmocollin-3, Desmosomal glycoprotein II, Desmosomal glycoprotein III, DSC2 and CDHF2, is a single-pass type I membrane protein which contains fivecadherin domains. The desmocollins are members of the desmosomal cadherin family of cell-cell adhesion molecules. They are essential constituents of desmosomes, intercellular junctions that play a critical role in the maintenance of tissue integrity in epithelia and cardiac muscle. In humans, three desmocollins (DSC1, DSC2 and DSC3) have been described. DSC2 / CDHF2 is component of intercellular desmosome junctions. It is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. DSC2 / CDHF2 may contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Defects in DSC2 are the cause of familial arrhythmogenic right ventricular dysplasia type 11 (ARVD11) also known as arrhythmogenic right ventricular cardiomyopathy 11 (ARVC11). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death.

References

Liu T., et al., 2005, J. Proteome Res. 4: 2070-80.
Khan,K. et al., 2006, Br J Cancer. 95 (10): 1367-70.
Ramachandran P., et al., 2006,J. Proteome Res. 5: 1493-503.
Syrris P., et al., 2006, Am. J. Hum. Genet. 79: 978-84.
Beffagna,G. et al., 2007, BMC Med Genet. 8: 65.

Sino Biological Inc. liefert DSC2 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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