DOPA Decarboxylase / DDC Antikörper

14.05.2012

Produkt-Information von DOPA Decarboxylase / DDC Antikörper

Immunogen	Recombinant Human DOPA Decarboxylase / DDC protein (Catalog#10560-H08B)
Antibody Type	Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
Clone ID	005
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	This antibody was obtained from a rabbit immunized with purified, recombinant Human DOPA Decarboxylase / DDC (rh DOPA Decarboxylase / DDC; Catalog#10560-H08B; NP_000781.1; Met 1-Glu 480).

Usage Guide von DOPA Decarboxylase / DDC Antikörper

Specificity

Human DOPA Decarboxylase / DDC

Immunochemistry

IHC-P: 5-10 μg/mL

DDC-brain immunohistochemistry

Immunochemical staining of human DDC in human brain with rabbit monoclonal antibody (5 μg/mL, formalin-fixed paraffin embedded sections).
The left panel: tissue incubated with primary antibody;
The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).

Western blot

This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human DDC in WB.

Direct ELISA

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human DDC.

Storage

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃.Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Verwandte Produkte & Themen von DOPA Decarboxylase / DDC Antikörper

Related Areas:

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
DOPA Decarboxylase/DDC	Human	DOPA Decarboxylase/DDC Protein, Recombinant	10560-H08B
DOPA Decarboxylase/DDC	Mouse	DDC / AADC Protein, Recombinant	50799-M08B

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human DOPA Decarboxylase/DDC	WB, ELISA	Mouse Monoclonal Antibody	10560-MM04
Human DOPA Decarboxylase/DDC	WB, ELISA	DOPA Decarboxylase/DDC Antibody, Rabbit MAb	10560-R040
Human DOPA Decarboxylase/DDC	WB, ELISA	Rabbit Polyclonal Antibody	10560-RP01
Human DOPA Decarboxylase/DDC	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10560-RP02
Human DOPA Decarboxylase/DDC	WB, ELISA	DOPA Decarboxylase / DDC Antibody	10560-R005

Hintergrund von DOPA Decarboxylase / DDC Antikörper

Dopa Decarboxylase (DDC), also known as AADC and Aromatic-L-amino acid decarboxylase, is a 54 kDa member of the group II decarboxylase family of proteins.It is a vitamin B6-dependent homodimeric enzyme that catalyzes the decarboxylation of both L-3,4-dihydroxyphenylalanine (L-DOPA) and L-5-hydroxytryptophan to dopamine and serotonin, respectively, which are major mammalian neurotransmitters and hormones belonging to catecholamines and indoleamines. Since L-DOPA is regularly used to treat the symptoms of Parkinson's disease, the catalytic pathway is of particular research interest. Defects of DDC are associated with severe developmental delay, oculogyric crises (OGC), as well as autosomal recessive disorder AADC deficiency, an early onset inborn error in neurotransmitter metabolism which can lead to catecholamine and serotonin deficiency.

References

Ichinose H. et al.,1989, Biochem Biophys Res Commun. 164: 1024-30.
Lisa J S. et al., 1992, Genomics 13: 469-71.
Moore P S. et al.,1996, Biochem J. 315: 249-56.
Bertoldi M. et al., 2003, Biochim Biophys Acta. 1647: 42-47.
Vassilacopoulou D. et al., 2004, Neurochem Res. 29: 1817-23.
Ma JZ. et al., 2005, Hum Mol Genet. 14: 1691-8.

Sino Biological Inc. liefert DOPA Decarboxylase / DDC Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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