DLL1 Antikörper

22.02.2012

Produkt-Information von DLL1 Antikörper

Immunogen	Recombinant Mouse DLL1 protein (Catalog#50522-M08H)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Mouse DLL1 (rM DLL1;Catalog#50522-M08H; NP_031891.2; Met 1-Gln 516). Total IgG was purified by Protein A affinity chromatography.

DLL1 Antikörper Usage Guide

Specificity	Mouse DLL1
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Mouse DLL1 in WB.
Direct ELISA	This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Mouse DLL1. The detection limit for Mouse DLL1 is approximately 0.039 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von DLL1 Antikörper

Delta-like protein 1, also known as Drosophila Delta homolog 1, H-Delta-1, and DLL1, is a single-pass type I membrane protein which contains one DSL domain and eight EGF-like domains. DLL1 is expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney. DLL1 acts as a ligand for Notch receptors. DLL1 blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor. The Notch pathway is an evolutionary conserved intercellular signaling pathway involved in numerous biological processes including cell fate determination, cellular differentiation, proliferation, survival, and apoptosis. In mammalian cells, five Notch ligands (Jagged1, 2, DLL1, DLL3, DLL4) and four Notch receptors (Notch 1-4) have been identified, and ligand-receptor interactions results in proteolysis and translocation of the Notch intracellular domain. Analysis of DLL1 mutants reveals that it is necessary and sufficient to maintain a pool of progenitors in the embryonic neuroepithelium. DLL1 serves to prevent the untimely differentiation of neural progenitors. DLL1 also contributes to the control of proliferation and differentiation in (Interfollicular Epidermis) IFE.

References

White, P. H. et al., 2005, Genesis. 42 (3): 193-202.
Miceli-Libby, L. et al., 2008, J Vasc Res. 45 (1): 1-9.
Segarra, M. et al., 2008, Blood. 112: 1904-11.
Moriyama,Y. et al., 2008, Int Immunol. 20 (6): 763-73.
Rocha,S.F. et al., 2009, Dev Biol. 328 (1): 54-65.

Sino Biological Inc. liefert DLL1 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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