Cynomolgus Interleukin 8 / IL8 Protein (Native)

28.04.2013

Sino Biological Inc. liefert Cynomolgus Interleukin 8 / IL8 Protein (Native) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Cynomolgus Interleukin 8 / IL8 Protein (Native) lesen Sie bitte: http://www.sinobiological.com/Interleukin-8-IL8-Protein-g-11622.html

Produkt-Information von Interleukin 8 / IL8 Protein

Synonym	IL8, CXCL8
Protein Construction	A DNA sequence encoding the cyno IL8 (P67814)(Ala23-Pro101) was expressed and purified with an initial Met.
Source	Cynomolgus
Expression Host	E.coli

QC Testing von Interleukin 8 / IL8 Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE IL8 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant cyno IL8 consists of 80 amino acids and has a calculated molecular mass of 9.3 KDa. It migrates as an 9 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile 50mM Tris, 250mM NaCl, pH 7.5. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von Interleukin 8 / IL8 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von Interleukin 8 / IL8 Protein

Interleukin 8, also known as IL8, is a chemokine produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL8 in their storage vesicles.IL8 is secreted and is an important mediator of the immune reaction in the innate immune system response. Interleukin 8 has two primary functions. It induces chemotaxis in target cells, primarily neutrophils but also other granulocytes, causing them to migrate toward the site of infection. Interleukin 8 also induces phagocytosis once they have arrived. Interleukin 8 is also known to be a potent promoter of angiogenesis. In target cells, IL8 induces a series of physiological responses required for migration and phagocytosis, such as increase of intracellular Ca2+, exocytosis (e.g. histamine release), and respiratory burst. Interleukin 8 is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. Interleukin 8 is often associated with inflammation. High levels of IL8 have been shown to reduce the likelihood of positive responses to antipsychotic medication in schizophrenia.

References

Modi WS. et al., 1990, Hum Genet. 84 (2): 185-7.
Utgaard JO. et al., 1998, J Exp Med. 188 (9): 1751-6.
Wolff B. et al., 1998, J Exp Med. 188 (9): 1757-62.