Cynomolgus IL23R / IL23 Receptor Protein

Sino Biological Inc. liefert Cynomolgus IL23R / IL23 Receptor Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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Produkt-Information von IL23R / IL23Receptor Protein

QC Testing von IL23R / IL23Receptor Protein

Purity	> 90 % as determined by SDS-PAGE	SDS-PAGE: IL23R protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Gly 24
Molecular Mass	The recombinant cynomolgus IL23R is a disulfide-linked homodimer. The reduced monomer comprises 571 amino acids and has a calculated molecular mass of 64.9 KDa.The apparent molecular mass of cynomolgos IL23R  is approximately 92 KDa respectively in SDS-PAGE.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von IL23R / IL23Receptor Protein

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Beschreibung von IL23R / IL23Receptor Protein

IL23R, also known as IL23Receptor, is a member of the type I cytokine receptor family, Type 2 subfamily. It contains 2 fibronectin type-III domains and is expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. IL23R associates with IL12RB1 to form the interleukin-23 receptor. It binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. Genetic variations in IL23R are associated with inflammatory bowel disease type 17 (IBD17). IBD17 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. Genetic variations in IL23R also can cause susceptibility to psoriasis type 7.

References

1. Duerr RH. et al., 2006, Science. 314 (5804): 1461-3.
2. Cargill M. et al., 2007, Am J Hum Genet. 80 (2): 273-90.
3. Dubinsky MC. et al., 2007, Inflamm Bowel Dis. 13 (5): 511-5.
4. Tremelling M. et al., 2007, Gastroenterology. 132 (5): 1657-64.