Cynomolgus EPHA4 Protein

Produkt-Information von EPHA4 Protein

QC Testing von EPHA4 Protein

Purity	> 96 % as determined by SDS-PAGE	SDS-PAGE: EPHA4 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Val 20
Molecular Mass	The recombinant Cynomolgus EPHA4 is a disulfide-linked homodimer. The reduced monomer comprises 769 amino acids and has a calculated molecular mass of 85.4KDa.The apparent molecular mass of Cynomolgus EPHA4 heterodimer is approximately 95 KDa respectively in SDS-PAGE.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von EPHA4 Protein

Verwandte Produkte & Themen von EPHA4 Protein

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>EphA4

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>EphA4

Neuroscience>>Axon Guidance>>Ephrin & Eph Receptor>>EphA4

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>EphA4

Cancer>>Growth Factor & Receptor>>Ephrin & Eph Receptor>>EphA4

Beschreibung von EPHA4 Protein

Ephrin type-A receptor 4, also known as Tyrosine-protein kinase receptor SEK, Tyrosine-protein kinase TYRO1, EPH-like kinase 8, and EPHA4, is a single-pass type I membrane protein which belongs to the protein kinase superfamily and ephrin receptor subfamily. EPHA4 contains two fibronectin type-III domains, one protein kinase domain and one SAM (sterile alpha motif) domain. EPHA4 is a receptor for members of the ephrin-A family. EPHA4 binds to ephrin-A1, ephrin-A4 and ephrin-A5. It binds more poorly to ephrin-A2 and ephrin-A3. EPHA4 may play a role in a signal transduction process involved in hindbrain pattern formation. 

The ephrins (Eph) and Eph receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosyl- phosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. All ephrins share a conserved extracellular sequence, which most likely corresponds to the receptor-binding domain. In molecular biology, ephrins and Eph receptors are components of cell signaling pathways involved in animal development, and implicated in some cancers. Eph receptors are classified as receptor tyrosine kinases (RTKs), and form the largest sub-family of RTKs.

References

1. Flanagan J. et al., 1998,?Annual Review of Neuroscience.?21: 309-45.
2. Holder N. et al., 1999,? Development. 126?(10): 2033-44.
3. Wilkinson DG. et al., 2001,?Nat. Rev. Neurosci.?2?(3): 155-64.
4. Murai KK. et al., 2003,?Journal of Cell Science.?116?(14): 2823-32.
5. The MGC Project Team. 2004, Genome Res. 14: 2121-7.
6. Rikova K. et al., 2007, Cell 131: 1190-203.
7. Heibeck TH. et al., 2009, J. Proteome Res. 8:3852-61.

Sino Biological Inc. liefert Cynomolgus EPHA4 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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