Cynomolgus CD3D Protein (His Tag)

10.04.2012

Produkt-Information von CD3D Protein

Synonym	CD3D
Protein Construction	A DNA sequence encoding the Cynomolgus (Macaca fascicularis) CD3D (Q95LI8) extracellular domain (Met 1- Ala 105) was fused with a polyhistidine tag at the C-terminus.
Source	Cynomolgus
Expression Host	Human Cells

QC Testing von CD3D Protein

Purity	> 85 % as determined by SDS-PAGE	SDS-PAGE: CD3D protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Phe 22
Molecular Mass	The recombinant cynomolgus CD3D consists of 95 amino acids and has a calculated molecular mass of 11 kDa. The apparent molecular mass of the recombinant protein is approximately 25-35 KDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from 0.2μm filtered solution of PBS, pH7.4 Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CD3D Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Verwandte Produkte & Themen von CD3D Protein

Related Areas:

Cancer>>Cancer Stem Cell (CSC)>>CD3d

Immunology>>Adaptive Immunity>>T Cell>>T Cell Antigen Recognition>>CD3d

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>T Cell Antigen Recognition>>CD3d

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
CD3d/CD3 delta	Human	CD3d Protein, Recombinant	10981-H08H
CD3d/CD3 delta	Cynomolgus	CD3D Protein, Recombinant	90046-C08H

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat No
Human CD3d	WB, ELISA	Mouse Monoclonal Antibody	10981-MM08
Human CD3d	WB, ELISA	CD3d Antibody, Rabbit MAb	10981-R006
Human CD3d	WB, ELISA	Rabbit Polyclonal Antibody	10981-RP01
Human CD3d	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10981-RP02

Beschreibung von CD3D Protein

T-cell surface glycoprotein CD3 delta chain, also known as CD3D, is a single-pass type I membrane protein. CD3D, together with CD3-gamma, CD3-epsilon and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. The T cell receptor-CD3 complex is unique in having ten cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs). CD3D contains 1 ITAM domain and has been shown to interact with CD8A. Defects in CD3D cause severe combined immunodeficiency autosomal recessive T-cell-negative / B-cell-positive / NK-cell-positive (T-/B+/NK+ SCID) which is a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels.

References

Doucey MA. et al., 2003, J Biol Chem. 278 (5): 3257-64.
Call ME. et al., 2004, EMBO J. 23 (12): 2348-57.
Arnett KL. et al., 2004, Proc Natl Acad Sci. 101: 16268-73.
Kjer-Nielsen L. et al., 2004, Proc Natl Acad Sci. 101: 7675-80.
Fischer A. et al., 2005, Curr Opin Allergy Clin Immunol. 5 (6): 491-5.
Holst J. et al., 2008, Nature immunology. 9 (6): 658-66.

Sino Biological Inc. liefert Cynomolgus CD3D Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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