Cynomolgus CCL21 / SCYA21 Protein (Native)

04.06.2012

Produkt-Information von CCL21 / SCYA21 Protein

Synonym	CCL21
Protein Construction	A DNA sequence encoding the cyno CCL21 (Q8HYP5) (Met 1-Pro131) was expressed and purified.
Source	Cynomolgus monkey
Expression Host	Baculovirus-Insect cells

QC Testing von CCL21 / SCYA21 Protein

Purity	> 94 % as determined by SDS-PAGE	SDS-PAGE: CCL21 / SCYA21 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Ser 24
Molecular Mass	The recombinant cyno CCL21 consists of 108 amino acids and has a calculated molecular mass of 12 kDa. It migrates as an 16 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CCL21 / SCYA21 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von CCL21 / SCYA21 Protein

C-C motif chemokine 21, also known as 6Ckine, Beta-chemokine exodus-2. Secondary lymphoid-tissue chemokine, Small-inducible cytokine A21, CCL21 and SCYA21, is a secreted protein which belongs to the intercrine beta (chemokine CC) family. CCL21 / SCYA21 is highly expressed in high endothelial venules of lymph nodes, spleen and appendix. Intermediate levels of CCL21 / SCYA21 is found in small intestine, thyroid gland and trachea. Low level expression of CCL21 / SCYA21 in thymus, bone marrow, liver, and pancreas. It is also found in tonsil, fetal heart and fetal spleen. CCL21 / SCYA21 inhibits hemopoiesis and stimulates chemotaxis. CCL21 / SCYA21 shows preferential activity towards naive T-cells. It may play a role in mediating homing of lymphocytes to secondary lymphoid organs. CCL21 / SCYA21 has shown biological activities that include T cell, natural killer (NK) cell, and dendritic cell (DC) chemoattraction. Intratumoral administration of CCL21 / SCYA21 has potential as a neoadjuvant mmunotherapy for breast cancer.

References

Christopherson KW. et al., 2001, Blood. 98 (13): 3562-8.
Clark HF. et al., 2003, Genome Res. 13: 2265-2270.
Ashour AE. et al., 2007, Cancer Biol Ther. 6 (8): 1206-10.
Mumtaz M. et al., 2009, Oncol Rep. 21 (1): 153-8.

Sino Biological Inc. liefert Cynomolgus CCL21 / SCYA21 Protein (Native) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Cynomolgus CCL21 / SCYA21 Protein (Native) n lesen Sie bitte: http://www.sinobiological.com/CCL21-SCYA21-Protein-g-9075.html

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CCL21/6Ckine	Human	CCL21/6Ckine Protein, Recombinant, Native	10477-HNAB
CCL21/6Ckine	Cynomolgus	CCL21 / SCYA21 Protein, Recombinant, with Native	90138-CNAB