Cynomolgus ALK-7 / ALK7 / ACVR1C Protein

24.12.2012

Sino Biological Inc. liefert Cynomolgus ALK-7 / ALK7 / ACVR1C Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Cynomolgus ALK-7 / ALK7 / ACVR1C Protein lesen Sie bitte: http://www.sinobiological.com/ALK-7-ALK7-ACVR1C-Protein-g-10179.html

Produkt-Information von ALK-7 / ALK7 / ACVR1C Protein

Synonym	ACVR1C
Protein Construction	A DNA sequence encoding the cynomolgus ACVR1C (F7GDQ6) (Leu44-Glu113) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Source	Cynomolgus
Expression Host	Human Cells

QC Testing von ALK-7 / ALK7 / ACVR1C Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: ALK-7 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Gly 25
Molecular Mass	The recombinant cynomolgus ACVR1C is a disulfide-linked homodimer. The reduced monomer comprises 330 amino acids and has a calculated molecular mass of 36.6 KDa.The apparent molecular mass of cynomolgus CD38 is approximately 42-46 KDa respectively in SDS-PAGE.
Formulation	Lyophilized from sterile PBS, pH7.4 Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von ALK-7 / ALK7 / ACVR1C Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von ALK-7 / ALK7 / ACVR1C Protein

ALK-7, also known as ALK7 and ACVR1C, is a member of the ALK family. ALK-7 is a serine-threonine kinase that can cause the activation of one of the SMAD signal transducers, SMAD2. It induces cell death by apoptosis through activation of the traditional TGF-beta pathway components in a process involving activation of SMAD2, SMAD3, caspase-3 and caspase-9. ALK-7 has a ligand known as Nodal. Nodal stimulates the secretion of TIMP-1 and inhibits matrix metalloproteinases MMP-2 and MMP-9 activity. The overexpression of Nodal or constitutively active ALK-7 decreases cell migration and invasion, whereas knock-down of Nodal and ALK-7 has the opposite effects.

References

Lin YY. et al., 2012, Nature. 482 (7384): 251-5.
He C. et al., 2010, Hum Genet. 128 (5) :515-27.
Watanabe R. et al., 2008, Biochem Biophys Res Commun. 377 (3): 867-72.