Cynomolgus ALK-1 / ACVRL1 Protein

12.03.2013

Sino Biological Inc. liefert Cynomolgus ALK-1 / ACVRL1 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Cynomolgus ALK-1 / ACVRL1 Protein lesen Sie bitte: http://www.sinobiological.com/ALK-1-ACVRL1-Protein-g-10576.html

Produkt-Information von ALK-1 / ACVRL1 Protein

Synonym	ACVRL1
Protein Construction	A DNA sequence encoding the cynomolgus ACVRL1(Met1-Gln118) was expressed with the Fc region of human IgG1 at the C-terminus.
Source	Cynomolgus
Expression Host	Human Cells

QC Testing von ALK-1 / ACVRL1 Protein

Purity	> 90 % as determined by SDS-PAGE	SDS-PAGE: ALK-1 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Asp 22
Molecular Mass	The recombinant cynomolgus ACVRL1 is a disulfide-linked homodimer. The reduced monomer comprises 338 amino acids and has a calculated molecular mass of 37.8 KDa.The apparent molecular mass of the protein is approximately 53 KDa respectively in SDS-PAGE.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von ALK-1 / ACVRL1 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage.Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von ALK-1 / ACVRL1 Protein

ALK1 is a type I cell-surface receptor for the TGF-beta superfamily of ligands. The heteromeric receptor complex consists of two types (I and II) transmembrane serine/threonine kinases, among which, constitutively active Type II receptors phosphorylate and activate type I receptors on ligand binding, and in turn, type I kinase phosphorylates down stream signal molecules including various SMAD transcriptional regulators. ALK1 shares a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail with other activin receptor-like kinase proteins. ALK1 has been suggested to be implicated in the blood vessel development and repair. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.

References

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Johnson DW. et al., 1996, Nat Genet. 13: 189-95.
Shoukier M. et al., 2008, Clin Genet. 73: 320-30.