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Cyclin A1 / CCNA1 Antikörper

Produkt-Information von Cyclin A1 / CCNA1 Antikörper

Immunogen

Recombinant Human Cyclin A1 / CCNA1 protein (Catalog#11013-H07B)

Antibody Type Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type

Rabbit IgG

Formulation 0.2 μm filtered solution in PBS with 5% trehalose
Preparation

Produced in rabbits immunized with purified, recombinant Human Cyclin A1 / CCNA1 (rh Cyclin A1 / CCNA1; Catalog#11013-H07B; NP_003905.1; Met 1-Gln 465). Total IgG was purified by Protein A affinity chromatography.

Usage Guide von Cyclin A1 / CCNA1 Antikörper

Specificity

Human Cyclin A1 / CCNA1

Western blot This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human CCNA1 in WB. Using a DAB detection system, the detection limit for Human CCNA1 is approximately 0.5 ng/lane under non-reducing conditions and reducing conditions.
Direct ELISA This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human CCNA1 . The detection limit for Human CCNA1 is approximately 0.00975 ng/well.
Storage This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Verwandte Produkte & Themen von Cyclin A1 / CCNA1 Antikörper

Related Areas:

Cancer>>Cell Cycle>>Cyclin>>Cyclin A1/CCNA1

Proteins:
Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
Cyclin A1/CCNA1 Human Cyclin A1/CCNA1 Protein, Recombinant 11013-H07B
Antibodies:
Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human
Cyclin A1/CCNA1
WB, ELISA Cyclin A1/CCNA1 Antibody, Mouse MAb 11013-MM02
Human
Cyclin A1/CCNA1
WB, ELISA Cyclin A1 / CCNA1 Antibody 11013-RP01

Hintergrund von Cyclin A1 / CCNA1 Antikörper

Cyclin-A1, also known as CCNA1, is a nucleus protein which belongs to thecyclin family and Cyclin AB subfamily. The expression of Cyclin-A1 (CCNA1) is increased in early G1 phase and reaches highest levels during the S and G2/M phases. The mammalian A-type cyclin family consists of two members, Cyclin-A1 (CCNA1) and Cyclin-A2 (CCNA2). CCNA2 promotes both G1/S and G2/M transitions, and targeted deletion of Ccna2 in mouse is embryonic lethal Cyclin-A1 (CCNA1) is expressed in mice exclusively in the germ cell lineage and is expressed in humans at highest levels in the testis and certain myeloid leukaemia cells. Cyclin-A1 (CCNA1) is essential for spermatocyte passage into the first meiotic division in male mice, a function that cannot be complemented by the concurrently expressed B-type cyclins. Cyclin-A1 (CCNA1) may be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. Cyclin-A1 (CCNA1) may function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. Cyclin-A1 (CCNA1) interacts with the CDK2 and the CDC2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.

References

  1. Yang R., et al., 1997, Cancer Res. 57: 913-20.
  2. Liu, D. et al., 1998, Nat Genet. 20 (4): 377-80.
  3. Yang R., et al., 1999, Mol. Cell. Biol. 19: 2400-7.
  4. Diederichs S., et al., 2004, J. Biol. Chem. 279: 33727-41.

Sino Biological Inc. liefert Cyclin A1 / CCNA1 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Cyclin A1 / CCNA1 Antikörper lesen Sie bitte: http:www.sinobiological.com/Cyclin-A1-CCNA1-Antibody-g-9274.html

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