CXCL12 / SDF-1 (isoform a) Protein

Produkt-Information von CXCL12 / SDF-1 Protein

QC Testing von CXCL12 / SDF-1 Protein

Purity	> 97 % as determined by SDS-PAGE	SDS-PAGE: CXCL12 / SDF-1 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Lys 22
Molecular Mass	The recombinant human CXCL12 consists of 68 amino acids and predicts a molecular mass of 8 KDa.
Formulation	Lyophilized from 0.2μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CXCL12 / SDF-1 Protein

Verwandte Produkte & Themen von CXCL12 / SDF-1 Protein

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>CXCL12/SDF-1 beta

Immunology>>Cytokine & Receptor>>Chemokine & Receptor>>CXCL12/SDF-1 beta

Beschreibung von CXCL12 / SDF-1 Protein

Stromal cell-derived factor 1, also known as C-X-C motif chemokine 12, Intercrine reduced in hepatomas, Pre-B cell growth-stimulating factor, SDF-1, PBSF, CXCL12 and SDF1, is a secreted protein which belongs to the intercrine alpha (chemokine CxC) family. CXCL12 / SDF-1 is widely expressed in various organs including heart, liver, brain, kidney, skeletal muscle, and lymphoid organs, and is highly conserved between species. CXCL12 / SDF-1 is expressed in two isoforms from a single gene that encodes two splice variants, SDF1α and SDF1β, which are identical except for the four residues present in the C-terminus of SDF1β but absent from SDF1α. As a highly efficacious lymphocyte chemoattractant, CXCL12 / SDF-1 activates and directs the migration of leukocytes in response to proinflammatory stimuli such as LPS, TNF, or interleukins. It has been demonstrated that CXCL12 / SDF-1 promotes tumor growth and malignancy, enhances tumor angiogenesis, participates in tumor metastasis, and thus plays an important role in carcinoma pathogenesis. In addition, CXCL12 / SDF-1 is identified as the biological ligand for CXC-chemokine receptor 4 (CXCR4), which is widely expressed in leukocytes and acts as the cofactor for HIV-1 entry, and inhibits the HIV-1 infection. Furthermore, SDF1 is rapidly inactivated via N-terminal processing by cathepsin G associated with the membrane of B-cells, NK cells and to a lesser extent, T-cells.

References

1. Bleul CC. et al., 1996, Nature. 382: 829-33.
2. Sapede D. et al., 2005, Proc Natl Acad Sci. 102: 1714-8.
3. Delgado MB. et al., 2001, Eur J Immunol. 31: 699-707.
4. Orimo A. et al., 2005, Cell. 121: 335-48.
5. Kryczek I. et al., 2007, Am J Physiol Cell Physiol. 292: C987-95.
6. Bbalabanian K. et al., 2005, J Biol Chem. 280: 35760-6.

Sino Biological Inc. liefert CXCL12 / SDF-1 (isoform a) Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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