CTLA-4 / CD152 Antikörper (Antigen Affinität reinigt)

07.03.2012

Produkt-Information von CTLA-4 / CD152 Antikörper

Immunogen	Recombinant Mouse CTLA-4 / CD152 protein (Catalog#50503-M08H)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Mouse CTLA-4 / CD152 (rM CTLA-4 / CD152; Catalog#50503-M08H; NP_033973.2; Met 1-Phe 162). CTLA-4 / CD152 specific IgG was purified by Mouse CTLA-4 / CD152 affinity chromatography.

CTLA-4 / CD152 Antikörper Usage Guide

Specificity	Mouse CTLA-4 / CD152
Western blot	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse CTLA4 in WB. Using a DAB detection system, the detection limit for Mouse CTLA4 is approximately 1 ng/lane under non-reducing conditions and 2 ng/lane under reducing conditions.
Direct ELISA	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse CTLA4. The detection limit for Mouse CTLA4 is approximately 0.00245 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von CTLA-4 / CD152 Antikörper

Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulinsuperfamily. It is widely expressed with highest levels in lymphoid tissues. CTLA4 contains aextracellularVdomain, a transmembranedomain, and a cytoplasmictail. Alternate splice variants encoding differentisoforms have been characterized. CTLA4 is similar to the T-cell costimulatory protein CD28 since both of the molecules bind toCD80andCD86on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found inregulatory T cellsand may play an important role in their functions. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA4. Genetic variations of CTLA4 have been associated with susceptibility to systemic lupus erythematosus (SLE), Graves disease (GRD), Celiac disease type 3 (CELIAC3) and Hepatitis B virus infection (HBV infection).

References

Dariavach, P. et al.,1988,Eur. J. Immunol. 18 (12): 1901-5.
Waterhouse, P. et al., 1995.Science. 270 (5238): 985-8.
Magistrelli, G. et al.,1999,Eur. J. Immunol. 29 (11): 3596-602.
Schneider, H. et al., 2006, Science. 313 (5795): 1972-5.
Rudd, CE. et al., 2009, Immunol. Rev. 229 (1): 12-26.

Sino Biological Inc. liefert CTLA-4 / CD152 Antikörper (Antigen Affinität reinigt) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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