CSEN / Calsenilin / KCNIP3 Protein (His Tag)

30.05.2013

Sino Biological Inc. liefert CSEN / Calsenilin / KCNIP3 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über CSEN / Calsenilin / KCNIP3 Protein (His Tag) lesen Sie bitte:http://www.sinobiological.com/CSEN-calsenilin-KCNIP3-Protein-Antibody-a-6213.html

Produkt-Information von CSEN / Calsenilin / KCNIP3 Protein

Synonym	KCNIP3, CSEN, DREAM, KCHIP3
Protein Construction	A DNA sequence encoding the human KCNIP3 (Q9Y2W7-1) (Met1-Ile256) was expressed with a polyhistidine tag at the N-terminus.
Source	Human
Expression Host	E.coli

QC Testing von CSEN / Calsenilin / KCNIP3 Protein

Purity	> 85 % as determined by SDS-PAGE	SDS-PAGE: CSEN protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	His
Molecular Mass	The recombinant human KCNIP3 consists of 271 amino acids and predicts a molecular mass of 31.1 KDa. It migrates as an approximately 29 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile 50mM Tris, 100mM NaCl, 10% Glycerol, 1mM DTT, pH 8.0. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von CSEN / Calsenilin / KCNIP3 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von CSEN / Calsenilin / KCNIP3 Protein

CSEN, also known as calsenilin and KCNIP3, is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. CSEN also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. CSEN binds to the DRE element of genes including PDYN and FOS.

References

Buxbaum JD. et al., 1998, Nat Med. 4 (10): 1177-81.
Carrion AM. et al., 1999, Nature. 398 (6722): 80-4.
Burgoyne RD. et al., 2004, Trends Neurosci. 27 (4): 203-9.
Kashiwa A. et al., 2000, J Neurochem. 75 (1): 109-16.