Complement Factor H / CFH Antikörper

22.08.2012

Produkt-Informaiton Complement Factor H / CFH Antikörper

Immunogen	Recombinant Human Complement Factor H / CFH protein (Catalog#10714-H08H)
Antibody Type	Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
Clone ID	305
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	This antibody was obtained from a rabbit immunized with purified, recombinant Human Complement Factor H / CFH (rh Complement Factor H / CFH; Catalog#10714-H08H; NP_000177.2; Ser 860-Arg 1231).

Usage Guide von Complement Factor H / CFH Antikörper

Specificity	Human Complement Factor H / CFH
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human CFH in WB under non-reducing conditions and not recommended under reducing conditions.
Direct ELISA	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human CFH. The detection limit for Human CFH is approximately 0. 0195 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Hintergrund von Complement Factor H / CFH Antikörper

Complement factor H, also known as H factor 1, and CFH, is a secreted protein which contains 20Sushi (CCP / SCR) domains. It is a large soluble glycoprotein that circulates in human plasma (at a concentration of 500-800 micrograms per milliliter). The main job of CFH is to regulate the Alternative Pathway of the complement system, ensuring that the complement system is directed towards pathogens and does not damage host tissue. CFH regulates complement activation on self cells by possessing both cofactor activity for the Factor I mediated C3b cleavage, and decay accelerating activity against the alternative pathway C3 convertase, C3bBb. CFH protects self cells from complement activation but not bacteria/viruses. Due to the central role that CFH plays in the regulation of complement, there are many clinical implications arrising from aberrant CFH activity. Defects in CFH are the cause of complement factor H deficiency (CFH deficiency) and hemolytic-uremic syndrome (HUS). Genetic variation in CFH is associated with age-related macular degeneration type 4 (ARMD4) which is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world.

References

Schulz TF. et al., 1986, Eur. J. Immunol. 16: 1351-5.
Buddles MR.H. et al., 2000, Am. J. Hum. Genet. 66: 1721-2.
Hageman GS. et al., 2005, Proc. Natl. Acad. Sci. USA. 102: 7227-32.
Liu T. et al., 2005, J. Proteome Res. 4: 2070-80.
Gregory SG. et al., 2006, Nature. 441: 315-21.
Chen R. et al., 2009, J. Proteome Res. 8: 651-61.

Primary Antibody Products

Sino Biological Inc. liefert Complement Factor H / CFH Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Complement Factor H / CFH Antikörper lesen Sie bitte: http://www.sinobiological.com/Complement-Factor-H-CFH-Antibody-g-9473.html

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
Complement Factor H/CFH	Human	Complement Factor H/CFH Protein, Recombinant	10714-H08H

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human Complement Factor H/CFH	WB, ELISA	Complement Factor H/CFH Antibody, Rabbit PAb	10714-RP01
Human Complement Factor H/CFH	WB, ELISA	Complement Factor H/CFH Antibody, Rabbit PAb (Antigen Affinity Purified)	10714-RP02
Human Complement Factor H/CFH	WB, ELISA	Complement Factor H / CFH Antibody	10714-R305