CNTFR Antikörper

Ciliary neurotrophic factor receptor subunit alpha, also known as CNTF receptor subunit alpha, CNTFR-alpha, and CNTFR is a cell membrane protein which belongs to thetype I cytokine receptor family and Type 3 subfamily. CNTFR contains twofibronectin type-III domains and oneIg-like C2-type (immunoglobulin-like) domain. Ciliary neurotrophic factor (CNTF) is expressed in glial cells within the central and peripheral nervous systems. CNTF stimulates gene expression, cell survival or differentiation in a variety of neuronal cell types such as sensory, sympathetic, ciliary and motor neurons. CNTF is not essential for neural development, but instead acts in response to injury or other stresses. The CNTF receptor complex is most closely related to, and shares subunits with the receptor complexes for interleukin-6 and leukemia inhibitory factor. The specificity conferring alpha subunit of the CNTF complex (CNTFR alpha), is extremely well conserved across species, and has a distribution localized predominantly to the nervous system and skeletal muscle. CNTFR alpha lacks a conventional transmembrane domain and is thought to be anchored to the cell membrane by a glycosyl-phosphatidylinositol linkage.

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