CHI3L1 / YKL40 Antikörper

Verwandte Bereiche:

Proteine:

Antikörper:

Chitinase-3-like protein 1, also known as Cartilage glycoprotein 39, and CHI3L1, is a member of the glycosyl hydrolase 18 family. The principal sources of CHI3L1 are activated macrophages and chondrocytes, neutrophils, and some tissue and tumor cells. CHI3L1 is a secreted glycoprotein that is upregulated in a number of human cancers and in non-neoplastic disease states characterized by chronic inflammation and tissue remodeling. Increased serum levels of CHI3L1 parallel disease severity, poorer prognosis, and shorter survival in many human neoplasias, including cancers of the breast, colon, prostate, ovaries, brain, thyroid, lung, and liver. Increased serum CHI3L1 also correlates with disease severity in rheumatoid arthritis, osteoarthritis, liver fibrosis, inflammatory bowel disease, and bacterial septicemia. CHI3L1 can act as a fibroblast mitogen and can activate several signaling pathways. Elevated levels of CHI3L1 are associated with disorders exhibiting increased connective tissue turnover, such as rheumatoid arthritis, osteoarthritis, scleroderma, and cirrhosis of the liver. The ability of CHI3L1 to bind both proteins and carbohydrates allows potential interactions with a variety of cell-surface and extracellular-matrix proteins, proteoglycans, and polysaccharides, and thus CHI3L1 can interface between proteomics and glycomics. CHI3L1 may play an important role in the capacity of cells to respond to and cope with changes in their environment.

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