CFHR1 Protein (His Tag)

20.12.2012

Sino Biological Inc. liefert CFHR1 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über CFHR1 Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/CFHR1-Protein-g-10165.html

Produkt-Information von CFHR1 Protein

Synonym	CFHR1, CFHL, CFHL1, CFHL1P, CFHR1P, FHR1, HFL1, HFL2
Protein Construction	A DNA sequence encoding the human CFHR1 (Q03591) (Met1-Arg330) was expressed with a polyhistidine tag at the C-terminus.
Source	Human
Expression Host	Human Cells

QC Testing von CFHR1 Protein

Purity	> 95% as determined by SDS-PAGE	SDS-PAGE: CFHR1 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Glu 19
Molecular Mass	The recombinant human CFHR1 consists of 323 amino acids and predicts a molecular mass of 37.2 KDa. It migrates as an approximately 45 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CFHR1 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von CFHR1 Protein

CFHR1 is a member of the complement factor H protein family. It is a secreted protein which binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. The human complement factor H protein family consists of the complement and immune regulators factor H, the factor H-like protein 1(FHL-1) and five factor H-related proteins (CFHR-1 to -5). CFHR1 might be involved in complement regulation. It can associate with lipoproteins and may play a role in lipid metabolism.

References

Martínez-Barrica. et al., 2012, Invest Ophthalmol Vis Sci. 53 (3): 1087-94.
Leban N. et al., 2012, Int J Immunogenet. 39 (2): 110-3.
Kubista KE. et al., 2011, Mol Vis. 17: 2080-92.