CEACAM6 / CD66c Antikörper ( FITC )

Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), also known as nonspecific crossreacting antigen (NCA) and CD66c, is one of seven human CEACAM family members within the immunoglobulin superfamily. Human CEACAMs include type I transmembrane proteins (CEACAM-1, -3, and -4) and GPI-linked molecules (CEACAM- 5 through -8). There is no human CEACAM-2. Human CEACAM6 is a 90 kDa GPI-linked membrane protein consisting of a 34 aa signal sequence, a 286 aa extracellular domain (ECD) containing one N-terminal V-type Ig-like domain and two C2-type Ig-like domains., and a 24 aa hydrophobic C-terminal propeptide. The GPI membrane anchor is attached at the C-terminus following cleavage of the propeptide. CEACAM-6 is expressed by granulocytes and their progenitors. It is also expressed by epithelia of various organs and is upregulated in pancreatic and colon adenocarcinomas, as well as hyperplastic polyps. Resistance to adhesion-related apoptosis in tumor cells is conferred in the condition of CEACAM6 overexpression.

Sino Biological Inc. liefert CEACAM6 / CD66c Antikörper mit höherer Qualität und günstigen Kosten im Vergleich zu anderen globalen Lieferanten.

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