CEACAM3 / CD66d Antikörper

Verwandte Bereiche:

Proteine:

Antikörper:

Carcinoembryonic antigen-related cell adhesion molecule 3, also known as Carcinoembryonic antigen CGM1, CEACAM3 and CD66D, is a single-pass type I membrane protein which belongs to theimmunoglobulin superfamily and CEA family. There are two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, and seven CEACAM has been identified in humans including type I transmembrane proteins (CEACAM-1, CEACAM-3, CEACAM-4) and GPI-linked molecules (CEACAM-5, CEACAM-8). The highly glycosylated CEACAM1 contains one N-terminal V-type Ig-like domain and three C2-type Ig-like domains within its ECD, and one ITIM motif and a calmodulin binding site in the cytoplasmic region. It was described as an adhesion molecule mediating cell adhesion via both homophilic and heterophilic manners, and was detected on leukocytes, epithelia, and endothelia. Studies have revealed that CEACAM1 performs actions in multiple cellular processes including tissue differentiation, angiogenesis, apoptosis, metastasis, as well as the modulation of innate and adaptive immune responses. CEACAM3 / CD66D is a major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species. It plays an important role in the clearance of pathogens by the innate immune system. CEACAM3 / CD66D is responsible for RAC1 stimulation in the course of pathogen phagocytosis.

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