CD97 Antikörper ( FITC )

CD97 antigen, also known as CD97 antigen, Leukocyte antigen CD97, and CD97, is a multi-pass membrane protein which belongs to theG-protein coupled receptor 2 family and LN-TM7 subfamily. CD97 is broadly expressed and found on most hematopoietic cells, including activated lymphocytes, monocytes, macrophages, dendritic cells, and granulocytes. CD97 is also abundantly expressed by smooth muscle cells. It is expressed in thyroid, colorectal, gastric, esophageal and pancreatic carcinomas too. Expression are increased under inflammatory conditions in the CNS of multiple sclerosis and in synovial tissue of patients with rheumatoid arthritis. Increased expression of CD97 in the synovium is accompagnied by detectable levels of soluble CD97 in the synovial fluid. CD97 is a receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. It plays an essential role in leukocyte migration. CD97 is a novel marker expressed in dedifferentiated neoplastic human thyroid C-cells. CD97 and CD55 may facilitate adhesion of C-cell carcinoma to surrounding surfaces which would result in rapid tumor cell spread.

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