CD55 / DAF Antikörper ( FITC )

Sino Biological Inc. liefert CD55 / DAF Antikörper ( FITC ) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über CD55 / DAF Antikörper ( FITC ) lesen Sie bitte:http://www.sinobiological.com/CD55-Protein-Antibody-a-312.html

Produkt-Information von CD55 / DAF Antikörper

Usage Guide von CD55 / DAF Antikörper

Specificity	Human CD55 / DAF
	No cross-reactivity in ELISA with Human CD97
Flow Cytometry	Profile of anti-CD55 reactivity on K562 cells analyzed by flow cytometry. Flow cytometry was performed on a BD FACSCalibur flow cytometry system Please refer to www.sinobiological.com/Flow-Cytometry-FACS-Protocols-a-750.html for technical protocols.
Storage	This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Verwandte Produkte & Themen von CD55 / DAF Antikörper

Hintergrund von CD55 / DAF Antikörper

CD55, also well known as decay-accelerating factor (DAF), is a member of the RCA (regulators of complement activation) family characterized by four to 30 SCRs (short consensus repeats) in their plasma-exposed regions. This 70-75 kDa glycoprotein CD55 containing four SCR modules is involved in the regulation of the complement cascade. It interferes with the functions of C3 and C5 convertases in both the classical and alternative pathways by preventing the assembly of the C3bBb complex or accelerating the disassembly of preformed convertase, and thus disrupts the cascade and protects the host cells from damage. Antigens present on the CD55/DAF constitute determinant for the Cromer blood group system. CD55/DAF has been identified as a ligand for an activation-associated, seven-transmembrane lymphocyte receptor, CD97, which is a receptor mediating attachment and infection of several viruses and bacteria. In addition, it has been shown that CD55/DAF regulates the interplay between complement and T cell immunity in vivo, and thus may be implicated in immune and tumor biology. There are two variants of CD55 encoded by alternatively spliced transcripts, the predominant variant is a GPI-anchored membrane form ubiquitously expressed on cells exposed to plasma complement proteins, whereas a soluble form present at much lower level.

References

1. Bergelson, JM. et al., 1994, Proc. Natl. Acad. Sci. USA. 91: 6245-8.
2. Terstappen, LW. et al., 1992, J. Leuro. Biol. 52: 652-60.
3. Liu, J. et al., 2005, J. Exp. Med. 201: 567-77.
4. Madjd, Z. et al., 2004, Clin. Cancer. Res. 10: 2797-803.
5. Mikesch, JH. et al., 2007, Cell. Oncol. 28: 223-32.

Primary Antikörper von Sino Biological Inc.