Cathepsin L / CTSL / CTSL1 Antikörper

29.08.2012

Produkt-Information von Cathepsin L / CTSL / CTSL1 Antikörper

Immunogen	Recombinant Human Cathepsin L / CTSL / CTSL1 protein (Catalog#10486-H08H)
Antibody Type	Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
Clone ID	07
Ig Type	Mouse IgG1
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Cathepsin L / CTSL / CTSL1 (rh Cathepsin L / CTSL / CTSL1; Catalog#10486-H08H; NP_001903.1; Met 1-Val 333). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.

Usage Guide von Cathepsin L / CTSL / CTSL1 Antikörper

Specificity	Human Cathepsin L / CTSL / CTSL1
	No cross-reactivity in ELISA with Human cell lysate (293 cell line)
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human CTSL in WB.
Direct ELISA	This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human CTSL. The detection limit for Human CTSL is approximately 0.0195 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Verwandte Produkte & Themen von Cathepsin L / CTSL / CTSL1 Antikörper

Related Areas:

Enzyme>>Protease & Regulator>>Cysteine Protease & Regulator>>Cathepsin Family>>Cathepsin L/CTSL/CTSL1

Cancer>>Angiogenesis>>Cathepsin Family>>Cathepsin L/CTSL/CTSL1

Immunology>>Innate Immunity>>Lysosomal Enzyme>>Cathepsin Family>>Cathepsin L/CTSL/CTSL1

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
Cathepsin L/CTSL/CTSL1	Human	Cathepsin L/CTSL Protein, Recombinant	10486-H08H
Cathepsin L/CTSL/CTSL1	Mouse	Cathepsin L/CTSL Protein, Recombinant	50015-M08H

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human Cathepsin L/CTSL/CTSL1	WB, ELISA	Cathepsin L / CTSL / CTSL1 Antibody	10486-MM07
Human Cathepsin L/CTSL/CTSL1	WB, ELISA	Cathepsin L/CTSL Antibody, Rabbit PAb	10486-RP01
Human Cathepsin L/CTSL/CTSL1	WB, ELISA	Cathepsin L/CTSL Antibody, Rabbit PAb (Antigen Affinity Purified)	10486-RP02
Mouse Cathepsin L/CTSL/CTSL1	WB, ELISA	Cathepsin L / CTSL Antibody (Antigen Affinity Purified)	50015-RP02

Hintergrund von Cathepsin L / CTSL / CTSL1 Antikörper

Cathepsin L is a lysosomal cysteine protease that plays a major role in intracellular protein catabolism, and is potent in degrading collagen, laminin, elastin, as well as alpha-1 protease inhibitor and other structural proteins of basement membranes. Like many proteases, Cathepsin L is synthesized as an inactive preproenzyme, and cleavage of the 96-residue proregion is necessary to generate the fully active 221-residue mature enzyme. Studies have demonstrated that cleavage of the proregion occur autocatalytically under acidic conditions. Cathepsin L is synthesized in large amounts and secreted by many malignantly transformed cells, and induced by growth factors and tumor promoters. In addition to its role in protein degradation, evidence has accumulated for the participation of Cathepsin L in various physiological and pathological processes, such as tumor invasion and metastasis, bone resorption, spermatogenesis, and arthritis. Accordingly, Cathepsin L may prove useful as a diagnostic or prognostic marker of human tumor malignancy.

References

Mason, R.W. et al., 1989, Biochem. J. 257: 125-129.
Chauhan, SS. et al., 1991, Cancer. Res. 51: 1478-1481.
Chauhan, SS. et al., 1993. J. Biol. Chem. 268: 1039-1045.
Menard, R et al., 1998, J. Biol. Chem. 273: 4478-4484.
Cailhier, JF. et al., 2008. J. Biol. Chem. 283: 27220-27229.

Sino Biological Inc. liefert Cathepsin L / CTSL / CTSL1 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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