CD31 / PECAM1 Antikörper

The CD31 adhesion molecule, also known as platelet-endothelial cell adhesion molecule-1 (PECAM-1), is a 130-kDa transmembrane glycoprotein expressed by endothelial cells, platelets, monocytes, neutrophils, and certain T cell subsets, and is the only known member of the CAM family on platelets. PECAM-1 has six Ig-homology domains that share sequence similarity with cellular adhesion molecules within the extracellular region, and an immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region. Accordingly, CD31acts as a signaling molecule when appropriately engaged and creates docking sites for the Src homology 2 domain-bearing protein tyrosine phosphatase (SHP)-1 and SHP-2. PECAM-1 mediates the homotypic or heterotypic cell adhesion by binding to itself or the leukocyte integrin αvβ3, and thus plays a role in neutrophil recruitment in inflammatory responses, transendothelial migration of leukocytes, as well as in cardiovascular development. In addition, it has been shown that CD31 expression is up-regulated by LPS stimulation, and might function as a feedback negative regulator of LPS inflammatory response in macrophages.

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