CD27 / TNFRSF7 Protein

Sino Biological Inc. liefert CD27 / TNFRSF7 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über CD27 / TNFRSF7 Protein lesen Sie bitte: http://www.sinobiological.com/CD27-TNFRSF7-Protein-g-9932.html

Produkt-Information von CD27 / TNFRSF7 Protein

QC Testing von CD27 / TNFRSF7 Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: CD27 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Ala 20
Molecular Mass	The recombinant human CD27/rFc is a disulfide-linked homodimer. The reduced monomer comprises 396 amino acids and has a predicted molecular mass of 44.4 kDa. The apparent molecular mass of the protein is approximately 63 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CD27 / TNFRSF7 Protein

Verwandte Produkte & Themen von CD27 / TNFRSF7 Protein

Cancer>>Cancer Stem Cell (CSC)>>CD27/TNFRSF7

Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>CD27/TNFRSF7

Immunology>>Adaptive Immunity>>T Cell>>Regulatory T Cell>>CD27/TNFRSF7

Immunology>>Cytokine & Receptor>>TNF Superfamily>>CD27/TNFRSF7

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD27/TNFRSF7

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Other>>CD27/TNFRSF7

Immunology>>Cluster of Differentiation>>Natural Killer (NK) Cell CD Antigen>>CD27/TNFRSF7

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Regulatory T Cells>>CD27/TNFRSF7

Beschreibung von CD27 / TNFRSF7 Protein

CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B-cell differentiation, activation and immunoglobulin synthesis. The CD27 receptor transduces signals and subsequently leads to the activation of NF-kappaB and MAPK8/JNK, and during which, adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling processes. In addition, a proapoptotic protein named SIVA, is capable of binding the cytoplasmic tail of CD27 and exerts action in the process of apoptosis.

References

1. Borst J. et al., 2005, Curr Opin Immunol. 17: 275-81.
2. Kobata T. et al., 1995, Proc Natl Acad Sci. 92: 11249-53.
3. Jacquot S. 2000, Immunol Res. 21: 23-30.
4. Arens R. et al., 2004, J Immunol. 173: 3901-8.
5. Akiba H. et al., 1998, J Biol Chem. 273: 13353-8.
6. Fortin A. et al., 2004, J Biol Chem. 279: 28706-14.