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CD21 Antikörper

Produkt-Information von CD21 Antikörper

Immunogen

Recombinant Human CD21 protein (Catalog#10811-H08H)

Antibody Type Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )

Clone ID

005

Ig Type

Rabbit IgG

Formulation 0.2 μm filtered solution in PBS with 5% trehalose
Preparation

This antibody was obtained from a rabbit immunized with purified, recombinant Human CD21 (rh CD21; Catalog#10811-H08H; P20023-1; Met 1-Arg 971).

Usage Guide von CD21 Antikörper

Specificity

Human CD21

Immunochemistry

IHC-P: 1-10 μg/mL

CD21-tonsil immunohistochemistry

Immunochemical staining of human CD21 in human tonsil with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to germinal center.
The left panel: tissue incubated with primary antibody;
The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).

Western blot This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human CD21 in WB. Using a DAB detection system, the detection limit for Human CD21 is approximately 1 ng/lane under non-reducing conditions and not recommended reducing conditions.
Direct ELISA This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human CD21. The detection limit for Human CD21 is approximately 0.00975ng/well.
Storage This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Verwandte Produkte & Themen von CD21 Antikörper

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Hintergrund von CD21 Antikörper

Complement receptor type 2, also known as Complement C3d receptor, Epstein-Barr virus receptor, EBV receptor, CD21 and CR2, is a single-pass type I membrane protein which belongs to thereceptors of complement activation (RCA) family. CD21 is tightly related to LFA-1 expression in (B-cell lymphoma) BCL and the absence of CD21 / LFA-1 expression is associated with pleural/peritoneal fluid involvement by BCL, a potential indicator of disease progression of BCL. CD21 / CR2 contains 15sushi (CCP/SCR) domains. CD21 / CR2 is a receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. CD21 / CR2 participates in B lymphocytes activation. Genetic variations in CD21 / CR2 are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.

References

  1. Barel M. et al.,1998, Mol. Immunol. 35: 1025-1031.
  2. Prota A.E. et al.,2002, Proc. Natl. Acad. Sci. USA. 99: 10641-10646.
  3. Gregory S.G. et al.,2006, Nature. 441: 315-321.
  4. Rikova K. et al., 2007, Cell 131: 1190-1203.
  5. Wollscheid B. et al.,2009, Nat. Biotechnol. 27: 378-386.

Sino Biological Inc. liefert CD21 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über CD21 Antikörper lesen Sie bitte: http:www.sinobiological.com/CD21-Antibody-g-9180.html

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