CD16 / FCGR3 Antikörper (Antigen Affinität reinigt)

15.02.2012

Produkt-Information von CD16 / FCGR3 Antikörper

Immunogen	Recombinant Mouse CD16 / FCGR3 protein (Catalog#50326-M08H)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Mouse CD16 / FCGR3 (rM CD16 / FCGR3; Catalog#50326-M08H; P08508-1; Met 1-Thr 215). CD16 / FCGR3 specific IgG was purified by Mouse CD16 / FCGR3 affinity chromatography.

CD16 / FCGR3 Antikörepr Usage Guide

Specificity	Mouse CD16 / FCGR3
Western blot	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse FCGR3 in WB. Using a DAB detection system, the detection limit for Mouse FCGR3 is approximately 0.5 ng/lane under non-reducing conditions and 1 ng/lane under reducing conditions.
Direct ELISA	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse FCGR3. The detection limit for Mouse FCGR3 is approximately 0.00245 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von CD16 / FCGR3 Antikörper

Low affinity immunoglobulin gamma Fc region receptor III, also known as IgG Fc receptor III, Fc-gamma RIII, FcRIII, FCGR3 and CD16, is a single-pass type I membrane protein. It is expressed on natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placental trophoblasts. Receptors that recognize the Fc portion of IgG function in the regulation of immune response and are divided into three classes designated CD64, CD32, and CD16. Mouse CD16 / FCGR3 is a receptor for the Fc region of complexed immunoglobulins gamma. It is a low affinity receptor. It contains twoIg-like C2-type (immunoglobulin-like) domains. In human, CD16 is expressed as two distinct forms (CD16a and CD16b) encoded by two different highly homologous genes in a cell type-specific manner. CD16b is a low-affinity, GPI-linked receptor expressed by neutrophils and eosinophils, whereas CD16a is an intermediate affinity polypeptide-anchored transmembrane glycoprotein expressed by a subset of T lymphocytes, natural killer (NK) cells, monocytes, and macrophages.

References

Morcos M. et al.,1994, Kidney Int. 46: 1627-34.
Gessner JE. et al. 1995, Immunobiology. 193: 341-55.
Takai T. et al., 2002, Nature Rev Immunol. 2: 580-92.
Barnes N et al., 2002, Immunity. 16: 379-89.
Galandrini R. et al.,2002, Blood. 100: 4581-9.
Kim M-K. et al., 2003, Blood. 101: 4479-84.
Nimmerjahn F. et al., 2006, Immunity. 24:19-28.
Webster NL. et al., 2006, J Leukoc Biol. 79: 294-302.

Sino Biological Inc. liefert CD16 / FCGR3 Antikörper (Antigen Affinität reinigt) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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