CD112 / Nectin-2 / PVRL2 Antikörper

CD112, also known as poliovirus receptor related 2 (PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily, and structurally comprises two Ig-like C2-type domains and one Ig-like V-type domain in the extracellular region. As a homophilic adhesion molecule, CD112 is widely expressed in human tissues including hematopoietic cells and mediates intercellular junctions of adjacent cells. This protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 can induce NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.

Sino Biological Inc. liefert CD112 / Nectin-2 / PVRL2 Antikörper mit höherer Qualität und günstigen Kosten im Vergleich zu anderen globalen Lieferanten.

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