Cathepsin E / CTSE Antikörper

14.02.2012

Produkt-Information von Cathepsin E / CTSE Antikörper

Immunogen	Recombinant Mouse Cathepsin E / CTSE protein (Catalog#50564-M08H)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Mouse Cathepsin E / CTSE (rM Cathepsin E / CTSE; Catalog#50564-M08H; NP_031825.2; Met 1-Pro 397). Total IgG was purified by Protein A affinity chromatography.

Cathepsin E / CTSE Antikörper Usage Guide

Specificity	Mouse Cathepsin E / CTSE
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Mouse CTSE in WB.
Direct ELISA	This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Mouse CTSE. The detection limit for Mouse CTSE is approximately 0.0049 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von Cathepsin E / CTSE Antikörper

Cathepsin E, also known as CTSE, is a member of the peptidase A1 family. Cathepsin E / CTSE is an aspartic protease that has been linked to antigen processing and innate immunity. Elevated levels of CTSE expression have also been associated with several forms of cancer, including carcinomas exhibiting highly invasive character. Elevated CTSE activity may play a functional role in the etiology of hepatocarcinogenesis. Cathepsin E / CTSE may have a role in immune function. It is probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. Cathepsin E / CTSE may play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain. Cathepsin E / CTSE is expressed abundantly in the stomach, the Clara cells of the lung and activated B-lymphocytes, and at lower levels in lymph nodes, skin and spleen. It is not expressed in resting B-lymphocytes.

References

Cook M. et al., 2001, Eur J Biochem. 268: 2658-68.
Ota T. et al., 2004, Nat Genet. 36:40-5.
Wild PJ. et al., 2005, Clin Cancer Res. 11 (12): 4415-29.
Caruso M. et al., 2009, Virchows Arch. 454 (3): 291-302.

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