Canine RBP4 Protein

05.06.2012

Produkt-Information von RBP4 Protein

Synonym	RBP4
Protein Construction	A DNA sequence encoding the canine RBP4 (F1PQI4) (Met1-Leu201) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Source	Canine
Expression Host	Human Cells

QC Testing von RBP4 Protein

Purity	>94% as determined by SDS-PAGE	SDS-PAGE: RBP4 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Glu 19
Molecular Mass	The recombinant canine RBP4 comprises 424 amino acids and has a predicted molecular mass of 48 kDa. The apparent molecular mass of the protein is approximately 53 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4 Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von RBP4 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Verwandte Produkte & Themen von RBP4 Protein

Related Areas:

Immunology>>Innate Immunity>>Acute Phase Proteins>>RBP4

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
RBP4	Human	RBP4 Protein, Recombinant	10354-H08H
RBP4	Mouse	RBP4 Protein, Recombinant	50170-M08H
RBP4	Canine	RBP4 Protein, Recombinant	70006-D02H
RBP4	Canine	RBP4 Protein, Recombinant	70006-D08H
RBP4	Rat	RBP4 Protein, Recombinant	80008-R08H

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human RBP4	WB, ELISA, IHC-P	Mouse Monoclonal Antibody	10354-MM01
Human RBP4	WB, ELISA	RBP4 / PRBP Antibody	10354-MM02
Human RBP4	WB, ELISA, IHC-P	RBP4 Antibody	10354-MM15
Human RBP4	WB, ELISA	Rabbit Polyclonal Antibody	10354-RP01
Human RBP4	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10354-RP02
Mouse RBP4	WB, ELISA	RBP4 Antibody, Rabbit PAb	50170-RP01
Mouse RBP4	WB, ELISA	RBP4 Antibody, Rabbit PAb (Antigen Affinity Purified)	50170-RP02
Rat RBP4	WB, ELISA	RBP4 Antibody (Antigen Affinity Purified)	80008-RP02

Beschreibung von RBP4 Protein

Retinol-binding protein 4 (RBP4) is the specific carrier for retinol (also known as vitamin A), and is responsible for the conversion of unstable and insoluble retinol in aqueous solution into stable and soluble complex in plasma through their tight interaction. As a member of the lipocalin superfamily, RBP4 containing a β-barrel structure with a well-defined cavity is secreted from the liver, and in turn delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP4-retinol complex interacts with transthyretin (TTR), and this binding is crucial for preventing RBP4 excretion through the kidney glomeruli. RBP4 expressed from an ectopic source efficiently delivers retinol to the eyes, and its deficiency affects night vision largely. In addition, RBP4 is recently identified as an adipokine whose dysregulation is closely associated with the pathogenesis of insulin resistance and type 2 diabetes, as well as obesity.

References

Colantuoni V. et al., 1983, Nucleic Acid Res. 11: 7769-76.
Loredana Q. et al., 2002, J Biol Chem. 277:30191-7.
Zanotti G. et al., 2004, Vitamins and Hormones. 69: 271-95.
Cho YM. et al., 2006, Diabetes Care. 29: 2457-61.
Balagopal P. et al., 2007, J Clin Endocirnol Metab. 92: 1971-4.

Sino Biological Inc. liefert Canine RBP4 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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