C4.4A / LYPD3 Antikörper

03.03.2012

Produkt-Information von C4.4A / LYPD3 Antikörper

Immunogen	Recombinant Mouse C4.4A / LYPD3 protein (Catalog#50546-M08H)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Mouse C4.4A / LYPD3 (rM C4.4A / LYPD3; Catalog#50546-M08H; NP_598504.1; Met 1-His 287). Total IgG was purified by Protein A affinity chromatography.

C4.4A / LYPD3 Antikörper Usage Guide

Specificity	Mouse C4.4A / LYPD3
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Mouse LYPD3 in WB.
Direct ELISA	This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Mouse LYPD3. The detection limit for Mouse LYPD3 is approximately 0.00975 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von C4.4A / LYPD3 Antikörper

Ly6 / PLAUR domain-containing protein 3, also known as GPI-anchored metastasis-associated protein C4.4A homolog, Matrigel-induced gene C4 protein, MIG-C4 and LYPD3, is a cell membrane protein which contains twoUPAR/Ly6 domains. Human LYPD3 contains twoUPAR/Ly6 domains. LYPD3 is expressed in placenta, skin and urothelium. It is found in suprabasal keratinocytes of chronic wounds. Weak expression of LYPD3 is found in esophagus and peripheral blood mononuclear cells. It is found in the majority of primary and metastatic transitional cell carcinomas (TCCs) and as well in breast cancer tissues, but not in adjacent normal tissues. High expression of LYPD3 is found in the tumor component of some noninvasive superficial lesions and in invasive and metastatic urothelial cancers. LYPD3 is up-regulated in migrating keratinocytes during epithelisation of incisional skin wounds. LYPD3 supports cell migration. It may be involved in urothelial cell-matrix interactions. It may also be involved in tumor progression.

References

Smith B.A., et al., 2001, Cancer Res. 61: 1678-85.
Wuerfel J., et al., 2001, Gene. 262: 35-41.
Clark H.F., et al., 2003, Genome Res. 13: 2265-70.
Fletcher G.C., et al., 2003, Br. J. Cancer. 88: 579-85.
Hansen L.V., et al., 2004, Biochem. Eng. J. 380: 845-57.

Sino Biological Inc. liefert C4.4A / LYPD3 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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