c-MET / HGFR (aa 956-1390) Protein (GST Tag)

Produkt-Information von c-MET / HGFR Protein

QC Testing von c-MET / HGFR Protein

Purity	> 97 % as determined by SDS-PAGE	SDS-PAGE: c-MET / HGFR protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant human MET /GST chimera consists of 672 amino acids and has a calculated molecular mass of 76.8 kDa. The recombinant protein migrates as an approximately 68 kDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of 20mM Tris,500mM NaCl, pH 7.4, 10%glycerol, 3mM DTT. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von c-MET / HGFR Protein

Verwandte Produkte & Themen von c-MET / HGFR Protein

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>HGFR/c-MET

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>HGFR/c-MET

Cancer>>Cancer Biomarkers>>HGFR/c-MET

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>HGFR/c-MET

Beschreibung von c-MET / HGFR Protein

The proto-oncogene MET encoded product MET (mesenchymal-epithelial transition factor), also known as c-Met or hepatocyte growth factor receptor (HGFR), is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. As the prototypic member of a small subfamily of growth factor receptors, c-Met/HGFR is synthesized as a single chain precursor, and is processed into a mature disulfide-linked heterodimer composed of a extracellular α subunit and a transmembrane β subunit via post-translational cleavage. c-Met/HGFR is identified as a glycosylated receptor tyrosine kinase (RTK), and HGF is the only known ligand. Following ligand binding and autophosphorylation, c-Met/HGFR transmits intercellular signals using a unique multisubstrate docking site which mediates the binding of multiple SH2-containing adapter proteins such as Grb2, SHC, Crk/CRKL, as well as Gab1. Normal c-Met/HGFR signaling is essential for embryonic development, tissue repair or wound healing, whereas aberrantly active c-Met/HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. Two transcript variants encoding different isoforms have been identified.

References

1. Bottaro DP. et al., 1991, Science. 251: 802-4.
2. Birchmeier C. et al., 2003, Nat Rev Mol Cell Biol. 4: 915-25.
3. Weidner KM. et al., 1996, Nature. 384: 173-6.
4. Pennacchietti S. et al., 2003, Cancer Cell. 3: 347-61.
5. Boccaccio C. et al., 2006, Nat Rev Cancer. 6: 637-45.
6. Chmielowiec J. et al., 2007, J Cell Biol. 177: 151-62.
7. Yu YL. et al., 2002, Cancer Res. 62: 2951-6.
8. Furge KA. et al., 2000, Oncogene. 19: 5582-9.

Sino Biological Inc. liefert c-MET / HGFR (aa 956-1390) Protein (GST Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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