BACE1 / ASP2 Antikörper ( FITC )

Sino Biological Inc. liefert BACE1 / ASP2 Antikörper ( FITC ) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über BACE1 / ASP2 Antikörper ( FITC ) lesen Sie bitte: http://www.sinobiological.com/BACE1-ASP2-Antibody-g-10068.html

Produkt-Information von BACE1 / ASP2 Antikörper

Usage Guide von BACE1 / ASP2 Antikörper

Specificity	Human BACE1 / ASP2
	Has cross-reactivity in ELISA with Mouse BACE1 Human ADAM15
Flow Cytometry	Flow cytometric analysis of Human BACE1 expression in Jurkat cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), and then stained with FITC Rabbit anti-BACE1 (10064-R027-F). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. Flow cytometry was performed on a BD FACSCalibur flow cytometry system Please refer to www.sinobiological.com/Flow-Cytometry-FACS-Protocols-a-750.html for technical protocols.
Storage	This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Verwandte Produkte & Themen von BACE1 / ASP2 Antikörper

Enzyme>>Protease & Regulator>>Aspartate Protease & Regulator>>BACE1/ASP2

Hintergrund von BACE1 / ASP2 Antikörper

As a member of the peptidase A1 protein family, BACE1 is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. This protease is responsible for the proteolytic processing of the amyloid precursor protein (APP). APP is cleaved to generate a 40 or 42 amino acid-long amyloid-β peptide, which is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimers disease (AD), and accordingly, BACE1 is implicated in the onset and progression of AD. The elevation of BACE1 levels can be induced by amyloid plaques surrounding neurons at early stages of pathology before neuron death occurs, and may drive a positive-feedback loop in AD. Different isoforms are derived from four transcript variants.

References

1. Vassar, R. et al., 1999, Science. 286: 735-741.
2. Yan, R. et al., 1999, Nature. 402: 533-537.
3. Johnston, JA. et al., 2005, Biochem. Soc. Trans. Nov. 33:1096-1100.
4. Zacchetti, D, et al., 2007, Neurodegener Dis. 4: 117-126.
5. Zhao, J. et al., 2007, J. Neurosci. 27: 3639-3649.

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