B2M / beta-2 microglobulin Antikörper

23.02.2012

B2M / beta-2 microglobulin Antibody Product Information

Immunogen	Recombinant Human B2M / beta-2 microglobulin protein (Catalog#11976-H08H)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Human B2M / beta-2 microglobulin (rh B2M / beta-2 microglobulin; Catalog#11976-H08H; NP_004039.1; Met 1-Met 119). Total IgG was purified by Protein A affinity chromatography.

B2M / beta-2 microglobulin Antikörper Usage Guide

Specificity	Human B2M / beta-2 microglobulin
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human B2M in WB.
Direct ELISA	This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Human B2M. The detection limit for Human B2M is approximately 0.039 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von B2M / beta-2 microglobulin Antikörper

Beta-2-microglobulin, also known as B2M, is a secreted protein which belongs to thebeta-2-microglobulin family. It contains oneIg-like C1-type (immunoglobulin-like) domain. Beta-2 microglobulin (B2M) plays a pivotal role in the biology of mammals, including its association with major histocompatibility complex (MHC) Class I gene products. The latter molecules have been shown to affect reproduction in both mice and humans. B2M forms the small invariable light chain subunit of class I HLA antigens on the cell membrane of all nucleated cells. During the continuous turnover of the HLA molecules. B2M is shed from the cell membrane into blood. Lymphocytes are the main source of serum free B2M. Serum B2M concentration is increased in renal diseases, various malignant diseases and some inflammatory and autoimmune disorders. In lymphatic malignancies serum B2M has significant prognostic value. B2M has been shown as a marker for monitoring inflammatory disease activity and it appears likely to have a destructive role in amyloidosis-related arthritis. B2M might be involved in the OA (osteoarthritis) pathogenesis. Defects in B2M are the cause of hypercatabolic hypoproteinemia. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation. B2M could be a potential therapeutic target in ovarian cancer.

References

Miyata T., et al.,1994 Biochemistry 33:12215-12221.
Remes,K. et al.,1996, Leuk Lymphoma21 (3-4): 233-8.
rinh C.H., et al., 2002, Proc. Natl. Acad. Sci. USA. 99: 9771-9776.
He X.H., et al., 2004, Sheng Wu Gong Cheng Xue Bao 20: 99-103.
Kihara M., et al., 2006, J. Biol. Chem. 281: 31061-31069.
Ricagno S.,et al., 2009, Biochem.Biophys.Res.Commun. 380: 543-547.

Sino Biological Inc. liefert B2M / beta-2 microglobulin Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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