B2M / beta-2 microglobulin Antikörper

22.08.2012

Produkt-Information von B2M / beta-2 microglobulin Antikörper

Immunogen	Recombinant Human B2M / beta-2 microglobulin protein (Catalog#11976-H08H)
Antibody Type	Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
Clone ID	219
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	This antibody was obtained from a rabbit immunized with purified, recombinant Human B2M / beta-2 microglobulin (rh B2M / beta-2 microglobulin; Catalog#11976-H08H; NP_004039.1; Met 1-Met 119).

Usage Guide von B2M / beta-2 microglobulin Antikörper

Specificity	Human B2M / beta-2 microglobulin
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human B2M in WB.
Direct ELISA	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human B2M. The detection limit for Human B2M is approximately 0.039 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Verwandte Produkte & Themen von B2M / beta-2 microglobulin Antikörper

Related Areas:

Immunology>>Adaptive Immunity>>Major Histocompatibility Complex>>B2M/beta-2 microglobulin

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
B2M/beta-2 microglobulin	Human	B2M/beta-2 microglobulin Protein, Recombinant	11976-H08H
B2M/beta-2 microglobulin	Mouse	B2M / Beta-2-microglobulin Protein, Recombinant	50957-M08H
B2M/beta-2 microglobulin	Rat	B2M / Beta-2-microglobulin Protein, Recombinant	80423-R08H
B2M/beta-2 microglobulin	Cynomolgus	B2M / Beta-2-microglobulin Protein, Recombinant	90152-C08H

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human B2M/beta-2 microglobulin	WB, ELISA	B2M / beta-2 microglobulin Antibody	11976-MM04
Human B2M/beta-2 microglobulin	WB, ELISA	B2M / beta-2 microglobulin Antibody	11976-RP01
Human B2M/beta-2 microglobulin	WB, ELISA	B2M / beta-2 microglobulin Antibody (Antigen Affinity Purified)	11976-RP02
Human B2M/beta-2 microglobulin	WB, ELISA	B2M / beta-2 microglobulin Antibody	11976-R219

Hintergrund von B2M / beta-2 microglobulin Antikörper

Beta-2-microglobulin, also known as B2M, is a secreted protein which belongs to thebeta-2-microglobulin family. It contains oneIg-like C1-type (immunoglobulin-like) domain. Beta-2 microglobulin (B2M) plays a pivotal role in the biology of mammals, including its association with major histocompatibility complex (MHC) Class I gene products. The latter molecules have been shown to affect reproduction in both mice and humans. B2M forms the small invariable light chain subunit of class I HLA antigens on the cell membrane of all nucleated cells. During the continuous turnover of the HLA molecules. B2M is shed from the cell membrane into blood. Lymphocytes are the main source of serum free B2M. Serum B2M concentration is increased in renal diseases, various malignant diseases and some inflammatory and autoimmune disorders. In lymphatic malignancies serum B2M has significant prognostic value. B2M has been shown as a marker for monitoring inflammatory disease activity and it appears likely to have a destructive role in amyloidosis-related arthritis. B2M might be involved in the OA (osteoarthritis) pathogenesis. Defects in B2M are the cause of hypercatabolic hypoproteinemia. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation. B2M could be a potential therapeutic target in ovarian cancer.

References

Miyata T., et al.,1994 Biochemistry 33:12215-12221.
Remes,K. et al.,1996, Leuk Lymphoma21 (3-4): 233-8.
Trinh C.H., et al., 2002, Proc. Natl. Acad. Sci. USA. 99: 9771-9776.
He X.H., et al., 2004, Sheng Wu Gong Cheng Xue Bao 20: 99-103.
Kihara M., et al., 2006, J. Biol. Chem. 281: 31061-31069.
Ricagno S.,et al., 2009, Biochem.Biophys.Res.Commun. 380: 543-547.

Primary Antibody Products

Sino Biological Inc. liefert B2M / beta-2 microglobulin Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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