Autotaxin / ENPP2 Antikörper (Antigen Affinität reinigt)

Autotaxin (ATX) also known as ectonucleotide pyrophosphatase / phosphodiesterase family member 2 (NPP2 or ENPP2). It belongs to the nucleotide pyrophosphatase /phosphodiesterase family. As a catalytic protein, Autotaxin possesses lysophospholipase D activity, and thus involved in cellular membrane lipid metabolism and remodeling. Autotaxin is discovered in human melanoma cells, has been gaining attention because it could be involved in cancer invasion and metastasis as an autocrine motility factor. Recent evidence has indicated that ATX is a key enzyme in the synthesis of lysophosphatidic acid (LPA), a lipid mediator with a wide range of biological actions including the stimulation of proliferation and contraction in hepatic stellate cells, a pivotal player in hepatic fibrosis. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. Thus, Autotaxin involves in several motility-related processes such as angiogenesis and neurite outgrowth. It was found acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Additionally, Autotaxin / ENPP2 was thought as a culprit protein for cancer, which potently stimulates cancer cell proliferation and tumor cell motility, augments the tumorigenicity and induces angiogenic responses.

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